Association of interleukin 1 beta polymorphisms and haplotypes with Alzheimer's disease

Author(s):Show less -

Marques Payao, Spencer Luiz ^{[1, 2]} ; Goncalves, Gisela Moraes ^[1] ; de Labio, Roger William ^[2] ; Horiguchi, Lie ^[2] ; Mizumoto, Igor ^[2] ; Rasmussen, Lucas Trevizani ^[2] ; de Souza Pinhel, Marcela Augusta ^[3] ; Silva Souza, Doroteia Rossi ^[3] ; Bechara, Marcelo Dib ^[4] ; Chen, Elizabeth ^[5] ; Mazzotti, Diego Robles ^[5] ; Ferreira Bertolucci, Paulo Henrique ^[6] ; Cardoso Smith, Marilia de Arruda ^[5]

Affiliation

^[1] USC, Sao Paulo - Brazil

^[2] Fac Med Marilia FAMEMA, Hemoctr, Disciplina Genet, Sao Paulo - Brazil

^[3] Fac Med Sao Jose do Rio Preto, Nucleo Pesquisa Bioquim & Biol Mol, Sao Paulo - Brazil

^[4] Univ Marilia UNIMAR, Fac Med, Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Escola Paulista Med UNIFESP EPM, Dept Morfol, Disciplina Genet, Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo, Escola Paulista Med UNIFESP EPM, Disciplina Neurol Ambulatorio Neurol Comportament, Sao Paulo - Brazil

• Document type: Journal article
• Source: Journal of Neuroimmunology; v. 247, n. 1-2, p. 59-62, JUN 15 2012.
• Web of Science Citations: 17

Abstract

Our study aimed to associate IL-1 beta and IL-1RN polyrnorphisms with AD disease in comparison with elderly control group from Sao Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1 beta) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population. (c) 2012 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 04/15273-3 - Characterization of ribosomal genes and of apolipoprotein AV and interleukin 6, 8 and 1st (alpha) polymorphisms in patients with Alzheimer's Disease
• Grantee: Spencer Luiz Marques Payão
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/15857-9 - Ribosomal gene expression of B-amyloid precursor protein, of presenilin and cytokines in brain and blood samples of Alzheimer's disease patients by Real Time PCR technique
• Grantee: Spencer Luiz Marques Payão
• Support Opportunities: Regular Research Grants
• FAPESP's process: 06/07240-3 - Lipids metabolism-related gene polymorphisms, diseases, laboratory exams in a Brazilian elderly cohort from districtal region of São Paulo
• Grantee: Marilia de Arruda Cardoso Smith
• Support Opportunities: Regular Research Grants