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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antihyperglycemic Effect of Casearia sylvestris Leaves Extract in Streptozotocin Induced Diabetic Rats

Author(s):
Buccioli, Paulo T. [1] ; Bortolin, Raul H. [1] ; Furini, Gleison T. [1] ; Cincotto, Danielli U. [1] ; Sousa, Janaina H. [1] ; Franca, Suzelei C. [1] ; Oliveira, Luciana R. A. [1] ; Pereira, Paulo S. [1]
Total Authors: 8
Affiliation:
[1] Univ Ribeirao Preto, Unidade Biotecnol, BR-14096900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Latin American Journal of Pharmacy; v. 31, n. 3, p. 421-426, APR 2012.
Web of Science Citations: 0
Abstract

The antihyperglycaemic effect of Casearia sylvestris aqueous extract (CS) and its flavonoidic fraction using in vivo models in streptozotocin-induced diabetic rats was evaluated. CS (500 mg/kg) reduced blood glucose in rats three weeks after a single oral dose. The blood glucose significantly decreased in a test of tolerance to insulin. Phytochemical investigation on TLC, HPLC-DAD and NMR spectral analysis of extract and fractions confirmed the presence of flavonoids. These results direct the hypothesis that CS improves glucose metabolism by reducing insulin resistance, and it may be useful for the treatment of type 2 diabetes. (AU)