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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Quantitative Evaluation of Acetaminophen in Oral Solutions by Dispersive Raman Spectroscopy for Quality Control

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Author(s):
Borio, Viviane G. [1] ; Vinha, Jr., Rubens [2] ; Nicolau, Renata A. [3] ; de Oliveira, Hueder Paulo M. [4] ; de Lima, Carlos J. [1] ; Silveira, Jr., Landulfo [1]
Total Authors: 6
Affiliation:
[1] Univ Camilo Castelo Branco Unicastelo, Biomed Engn Inst, BR-12247004 Sao Jose Dos Campos - Brazil
[2] FAAP, BR-12242020 Sao Jose Dos Campos - Brazil
[3] Univ Vale Paraiba Univap, Inst Res & Development IP&D, BR-12244000 Sao Jose Dos Campos - Brazil
[4] Univ Fed Pelotas UFPel, Ctr Chem Sci Pharmaceut & Food, BR-96010900 Pelotas, RS - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SPECTROSCOPY-AN INTERNATIONAL JOURNAL; v. 27, n. 4, p. 215-228, 2012.
Web of Science Citations: 2
Abstract

This work used dispersive Raman spectroscopy to evaluate acetaminophen in commercially available formulations as an analytical methodology for quality control in the pharmaceutical industry. Raman spectra were collected using a near-infrared dispersive Raman spectrometer (830 nm, 50 mW, 20 s exposure time) coupled to a fiber optic probe. Solutions of acetaminophen diluted in excipient (70 to 120% of the commercial concentration of 200 mg/mL) were used to develop a calibration model based on partial least squares (PLSs) applied to Raman spectra of solutions and, subsequently, obtain linearity, accuracy, precision (repeatability), and sensitivity of the method using the near-infrared spectroscopy (NIRS) as a gold standard method. This model was used to predict the acetaminophen concentration in commercial samples from different lots of acetaminophen formulations (200 mg/mL) with a PLS-prediction error of about 0.6%. Commercial medicines had PLS predicted concentrations errors below 2.5%, whereas NIRS had an error of about 3.7% compared to the label concentration. It has been demonstrated the applicability of Raman spectroscopy with fiber probe for quality control in pharmaceutical industry of commercial formulations. (AU)