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(Reference retrieved automatically from Google Scholar through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of steroid injection to newborn rats on serotonin activity in frontal cortex and raphe

Full text
Author(s):
Dominguez‚ R. ; Cruz-Morales‚ S.E. ; Carvalho‚ M.C. ; Xavier‚ M. ; Brandao‚ M.L.
Total Authors: 5
Document type: Journal article
Source: Neuroreport; v. 14, n. 4, p. 597-599, 2003.
Abstract

The effects of injecting testosterone propionate or estradiol benzoate to newborn rats on dopaminergic and serotoninergic activity in the frontal cortex, dorsal and median raphe nucleus were analyzed when animals reached adulthood. High performance liquid chromatography was used to measure tissue levels of dopamine, serotonin and its metabolites. Activity was calculated as the metabolite/neurotransmitter ratio. An increase in androgen or estrogen levels at birth caused a significant decrease in serotoninergic activity in the frontal cortex and in the dorsal raphe nucleus, without causing apparent changes in dopaminergic activity; serotinergic activity in the median raphe nucleus was not affected. The results suggest that the transmission of DA and 5-HT in these structures are differentially influenced by early androgenization or estrogenization. (AU)

FAPESP's process: 98/11187-2 - Neurobiology of fear and stress
Grantee:Marcus Lira Brandão
Support Opportunities: Research Projects - Thematic Grants