Therapeutic efficacy of the organic selenium /vitamin A association in a relapsing...
| Full text | |
| Author(s): |
Cetrulo Lorenzi, Julio Cesar
[1, 2]
;
Brum, Doralina G.
[3]
;
Zanette, Dalila L.
[1, 2]
;
Alves Souza, Alessandra de Paula
[2, 4]
;
Barbuzano, Fernanda Goncalves
[2]
;
dos Santos, Antonio Carlos
[5]
;
Barreira, Amilton Antunes
[3]
;
Silva, Jr., Wilson Araujo
[1, 2]
Total Authors: 8
|
| Affiliation: | [1] Univ Sao Paulo, Dept Genet, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
[2] Natl Inst Sci & Technol Stem Cell & Cell Therapy, Ribeirao Preto - Brazil
[3] Univ Sao Paulo, Dept Neurosci, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
[4] Univ Sao Paulo, Dept Immunol, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
[5] Univ Sao Paulo, Dept Internal Med, Med Sch Ribeirao Preto, BR-14049 Ribeirao Preto - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | International Journal of Neuroscience; v. 122, n. 8, p. 466-471, AUG 2012. |
| Web of Science Citations: | 32 |
| Abstract | |
The pathology of relapsing-remitting multiple sclerosis (RR-MS) is largely attributed to activated autoreactive effector T lymphocytes. The influence of microRNAs on the immune response has been shown to occur in different pathways of lymphocyte differentiation and function. Here, the expression of the miRNAs miR-15a/161 in PBMC, CD4(+), and CD8(+) from RR-MS patients has been investigated. BCL2, a known miR-15a/16-1 target, has also been analyzed. The results have shown that miR-15a/16-1 is downregulated in CD4(+) T cells, whereas BCL2 is highly expressed in RR-MS patients only. Our data suggest that miR-15a/16-1 can also modulate the BCL2 gene expression in CD4(+) T cells from RR-MS patients, thereby affecting apoptosis processes. (AU) | |
| FAPESP's process: | 98/14247-6 - Center for Research on Cell-Based Therapy |
| Grantee: | Marco Antonio Zago |
| Support type: | Research Grants - Research, Innovation and Dissemination Centers - RIDC |
| FAPESP's process: | 10/00310-1 - miRNA signature of T lymphocyte subpopulations from healthy and multiple sclerosis patients |
| Grantee: | Julio Cesar Cetrulo Lorenzi |
| Support type: | Scholarships in Brazil - Doctorate |