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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oral microbial colonization in patients with systemic lupus erythematous: correlation with treatment and disease activity

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Author(s):
de Araujo Navas, E. A. F. [1] ; Sato, E. I. [2, 3] ; Pereira, D. F. A. [1] ; Back-Brito, G. N. [1] ; Ishikawa, J. A. [1] ; Jorge, A. O. C. [1] ; Brighenti, F. L. [1] ; Koga-Ito, C. Y. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Paulista UNESP, Sao Jose dos Campos Dent Sch, Dept Oral Biosci & Diag, Microbiol Lab, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Div Rheumatol, Sao Paulo - Brazil
[3] Hosp Sao Paulo, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Lupus; v. 21, n. 9, p. 969-977, AUG 2012.
Web of Science Citations: 8
Abstract

Treating patients with systemic lupus erythematosus (SLE) with steroids and immunosuppressive drugs may interfere in the presence of potentially opportunistic microorganisms in the oral cavity. The aim of this study was to evaluate the presence of Candida spp., Staphylococcus spp., Enterobacteria and Pseudomonas spp. in the oral cavity of SLE patients, compared with healthy controls. A group of 40 patients who had received therapy for at least 60 days was selected (19-53 years). For the control group, 40 healthy individuals matched for age, gender and use of partial prosthesis were selected. Oral rinse samples were collected and plated on specific culture media. After incubation, the number of colony forming units (CFU) was obtained and the isolates were identified at species level. Microbial counts were compared between SLE and control by analysis of variance (ANOVA) and Mann-Whitney (p < 0.05 significant). Microorganism counts in patients with and without immunosuppressive drugs, as well with active and inactive disease (according to SLEDAI score) were also compared. No significant differences in CFU/mL between SLE and control patients were observed (yeasts, p = 0.55; Staphylococci, p = 0.24; Enterobacteria/Pseudomonas spp., p = 0.26). No differences in microbial counts were observed regarding clinical parameters tested. The most frequent species isolated in the SLE group were Candida albicans, Staphylococcus epidermidis and Klebsiella oxytoca. In conclusion, no differences in frequency and microorganism levels were found between SLE patients and healthy individuals. Lupus (2012) 21, 969-977. (AU)