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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?

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Author(s):
Moraes-Vieira, P. M. M. [1] ; Bassi, E. J. [1] ; Araujo, R. C. [2] ; Camara, N. O. S. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Dept Immunol, Inst Biomed Sci, BR-05508900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biophys, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Obesity Reviews; v. 13, n. 8, p. 733-743, AUG 2012.
Web of Science Citations: 16
Abstract

Food intake and nutritional status modify the physiological responses of the immune system to illness and infection and regulate the development of chronic inflammatory processes, such as kidney disease. Adipose tissue secretes immune-related proteins called adipokines that have pleiotropic effects on both the immune and neuroendocrine systems, linking metabolism and immune physiology. Leptin, an adipose tissue-derived adipokine, displays a variety of immune and physiological functions, and participates in several immune responses. Here, we review the current literature on the role of leptin in kidney diseases, linking adipose tissue and the immune system with kidney-related disorders. The modulation of this adipose hormone may have a major impact on the treatment of several immune- and metabolic-related kidney diseases. (AU)

FAPESP's process: 12/02270-2 - New cellular, molecular and immunological mechanisms involved in acute and chronic renal injury: the search for new therapeutical approaches
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants
FAPESP's process: 07/07139-3 - The role of heme oxygenase 1 in different renal inflammatory process in experimental animal models
Grantee:Niels Olsen Saraiva Câmara
Support type: Research Projects - Thematic Grants
FAPESP's process: 09/50450-7 - Adipokines in experimental transplantation: interaction between leptin and the development of immunological tolerance
Grantee:Pedro Manoel Mendes de Moraes Vieira
Support type: Scholarships in Brazil - Doctorate