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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Natural products from Brazilian biodiversity as a source of new models for medicinal chemistry

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Author(s):
Bolzani, Vanderlan da Silva [1] ; Valli, Marilia [1] ; Pivatto, Marcos [1] ; Viegas, Jr., Claudio [2]
Total Authors: 4
Affiliation:
[1] Univ Estadual Paulista, Dept Quim Inorgan, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Inst Quim, UNESP, BR-14801970 Araraquara, SP - Brazil
[2] Univ Fed Alfenas, Inst Quim, LFQM, BR-37130000 Alfenas, MG - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Pure and Applied Chemistry; v. 84, n. 9, p. 1837-1846, 2012.
Web of Science Citations: 24
Abstract

Natural products are the inspiration for many valuable therapeutic agents and attest to biodiversity being a rich source of new molecular structures. Their value as templates for medicinal chemistry remains undisputed, even after the growth of the combinatorial chemistry era. Tropical environments, such as Brazilian biomes, offer a particularly rich potential for biologically active compounds with unique structures and continue to contribute toward modern drug discovery. Our bioprospecting of plant species of the Cerrado and Atlantic Forest biomes has yielded promising bioactive secondary metabolites, and we describe some of these molecules and semisynthetic derivatives as potential acetylcholinesterase (AChE) inhibitors. (AU)

FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants