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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiovascular responses to glutamate microinjection in the dorsomedial periaqueductal gray of unanesthetized rats

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Author(s):
Pelosi, Gislaine Garcia [1, 2] ; Busnardo, Cristiane [1] ; Tavares, Rodrigo Fiacadori [1] ; Aguiar Correa, Fernando Morgan [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Sao Paulo - Brazil
[2] Univ Estadual Londrina, Dept Ciencias Fisiol, Ctr Biol Sci, BR-86055900 Londrina, Parana - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Neuroscience Research; v. 90, n. 11, p. 2193-2200, NOV 2012.
Web of Science Citations: 8
Abstract

The periaqueductal gray area (PAG) is a mesencephalic area involved in cardiovascular modulation. Glutamate (L-Glu) is an abundant excitatory amino acid in the central nervous system (CNS) and is present in the rat PAG. Moreover, data in the literature indicate its involvement in central blood pressure control. Here we report on the cardiovascular effects caused by microinjection of L-Glu into the dorsomedial PAG (dmPAG) of rats and the glutamatergic receptors as well as the peripheral mechanism involved in their mediation. The microinjection of L-Glu into the dmPAG of unanesthetized rats evoked dose-related pressor and bradycardiac responses. The cardiovascular response was significantly reduced by pretreatment of the dmPAG with a glutamatergic M-methyl-D-aspartate (NMDA) receptor antagonist (LY235959) and was not affected by pretreatment with a non-NMDA receptor antagonist (NBQX), suggesting a mediation of that response by the activation of NMDA receptors. Furthermore, the pressor response was blocked by pretreatment with the ganglion blocker pentolinium (5 mg/kg, intravenously), suggesting an involvement of the sympathetic nervous system in this response. Our results indicate that the microinjection of L-Glu into the dmPAG causes sympathetic-mediated pressor responses in unanesthetized rats, which are mediated by glutamatergic NMDA receptors in the dmPAG. (c) 2012 Wiley Periodicals, Inc. (AU)

FAPESP's process: 09/05308-8 - Role of the hypothalamus paraventricular nucleus on cardiovascular and neuroendocrine responses observed during acute restraint stress in rats
Grantee:Cristiane Busnardo Santiago
Support Opportunities: Scholarships in Brazil - Post-Doctoral