Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MMP-2 is not Altered By Stretching in Skeletal Muscle

Full text
Author(s):
Peviani, S. M. [1] ; Gomes, A. R. S. [2] ; de Araujo, H. S. Selistre [3] ; Salvini, T. F. [1]
Total Authors: 4
Affiliation:
[1] Univ Fed Sao Carlos, Dept Phys Therapy, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Fed Parana, Dept Phys Therapy, Matinhos - Brazil
[3] Univ Fed Sao Carlos, Dept Physiol, BR-13560 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 30, n. 7, p. 550-554, JUL 2009.
Web of Science Citations: 4
Abstract

Considering that short bouts of stretching, as recommended in rehabilitation and sports activities, induce skeletal Muscle and connective tissue adaptation, the hypothesis of this study was that MMP-2 activity is regulated by muscle stretch. The level of MMP-2 activity was, thereby, assessed after stretching in rat soleus muscle. Animals received a single session of stretching (10 stretches lasting 1 min each with 30s of rest in between) and were evaluated immediately and after 8, 24, 48, 72 and 168 h. To evaluate the effect of repetitive sessions of stretching, three groups of animals were evaluated - one group after 2 sessions, another after 3, and a third after 7. MMP-2 activity was evaluated by zymography and MMP-2 mRNA was assessed by real-time polymerase chain reaction. None of the groups presented MMP-9 activity. MMP-2 activity and mRNA expression did not change after either single or repetitive sessions of stretching. In conclusion, the results of this study indicate that MMP-2 is not involved in the muscle stretch-induced remodeling. (AU)