A simple and precise conductometric method for the determination of losartan in pharmaceutical products

Author(s)

Rossini, Pamela de Oliveira ^[1] ; Felix, Fabiana S. ^[1] ; Angnes, Lucio ^[1]

Affiliation

^[1] Univ Sao Paulo, Inst Quim, BR-05508000 Sao Paulo - Brazil

• Document type: Journal article
• Source: CENTRAL EUROPEAN JOURNAL OF CHEMISTRY; v. 10, n. 6, p. 1842-1849, DEC 2012.
• Web of Science Citations: 8

Abstract

Losartan is an antihypertensive agent that lost its patent protection in 2010, and, consequently, it has been available in generic form. The latter motivated the search for a rapid and precise alternative method. Here, a simple conductometric titration in aqueous medium is described for the losartan analysis in pharmaceutical formulations. The first step of the titration occurs with the protonation of losartan producing a white precipitate and resulting in a slow increase in conductivity. When the protonation stage is complete, a sharp increase in conductivity occurs which was determined to be due to the presence of excess of acid. The titrimetric method was applied to the determination of losartan in pharmaceutical products and the results are comparable with values obtained using a chromatographic method recommended by the United States Pharmacopoeia. The relative standard deviation for successive measurements of a 125 mg L-1 (2.71x10(-4) mol L-1) losartan solution was approximately 2%. Recovery study in tablet samples ranged between 99 and 102.4%. The procedure is fast, simple, and represents an attractive alternative for losartan quantification in routine analysis. In addition, it avoids organic solvents, minimizes the risk of exposure to the operator, and the waste treatment is easier compared to classical chromatographic methods. (AU)