| Full text | |
| Author(s): Show less - |
Lira, Fabio S.
[1, 2]
;
Rosa, Jose C.
[1]
;
Pimentel, Gustavo D.
[1]
;
Santos, Ronaldo V.
[3]
;
Carnier, June
[1]
;
Sanches, Priscila L.
[1]
;
de Piano, Aline
[1]
;
de Souza, Claudio T.
[2]
;
Tock, Lian
[1]
;
Tufik, Sergio
[4]
;
de Mello, Marco T.
[1, 4]
;
Seelaender, Marilia
[5, 6]
;
Oller do Nascimento, Claudia M.
[1]
;
Oyama, Lila M.
[1, 3]
;
Damaso, Ana R.
[1, 3]
Total Authors: 15
|
| Affiliation: | [1] Dept Fisiol, Sao Paulo - Brazil
[2] Univ So Santa Catarina, Hlth Sci Unit, Lab Exercise Biochem & Physiol, Criciuma, SC - Brazil
[3] Dept Biociencias, Sao Paulo - Brazil
[4] Dept Psicobiol, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo UNIFESP, Sao Paulo - Brazil
[6] ICB Univ Sao Paulo USP, Grp Metab & Canc, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | NUTRITION JOURNAL; v. 11, SEP 18 2012. |
| Web of Science Citations: | 17 |
| Abstract | |
Aim: The purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy. Design: The present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. In addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR). Results: The most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. In addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels. Conclusions: The present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. In addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways. (AU) | |
| FAPESP's process: | 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents |
| Grantee: | Ana Raimunda Dâmaso |
| Support Opportunities: | Regular Research Grants |