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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Long-term interdisciplinary therapy reduces endotoxin level and insulin resistance in obese adolescents

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Lira, Fabio S. [1, 2] ; Rosa, Jose C. [1] ; Pimentel, Gustavo D. [1] ; Santos, Ronaldo V. [3] ; Carnier, June [1] ; Sanches, Priscila L. [1] ; de Piano, Aline [1] ; de Souza, Claudio T. [2] ; Tock, Lian [1] ; Tufik, Sergio [4] ; de Mello, Marco T. [1, 4] ; Seelaender, Marilia [5, 6] ; Oller do Nascimento, Claudia M. [1] ; Oyama, Lila M. [1, 3] ; Damaso, Ana R. [1, 3]
Total Authors: 15
[1] Dept Fisiol, Sao Paulo - Brazil
[2] Univ So Santa Catarina, Hlth Sci Unit, Lab Exercise Biochem & Physiol, Criciuma, SC - Brazil
[3] Dept Biociencias, Sao Paulo - Brazil
[4] Dept Psicobiol, Sao Paulo - Brazil
[5] Univ Fed Sao Paulo UNIFESP, Sao Paulo - Brazil
[6] ICB Univ Sao Paulo USP, Grp Metab & Canc, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: NUTRITION JOURNAL; v. 11, SEP 18 2012.
Web of Science Citations: 16

Aim: The purpose of the present study was to assess the dietary fat intake, glucose, insulin, Homeostasis model assessment for insulin resistance HOMA-IR, and endotoxin levels and correlate them with adipokine serum concentrations in obese adolescents who had been admitted to long-term interdisciplinary weight-loss therapy. Design: The present study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (n = 18, aged 15-19 y) with a body mass index >95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. We collected blood samples, and IL-6, adiponectin, and endotoxin concentrations were measured by ELISA. Food intake was measured using 3-day diet records. In addition, we assessed glucose and insulin levels as well as the homeostasis model assessment for insulin resistance (HOMA-IR). Results: The most important finding from the present investigation was that the long-term interdisciplinary lifestyle therapy decreased dietary fat intake and endotoxin levels and improved HOMA-IR. We observed positive correlations between dietary fat intake and endotoxin levels, insulin levels, and the HOMA-IR. In addition, endotoxin levels showed positive correlations with IL-6 levels, insulin levels and the HOMA-IR. Interestingly, we observed a negative correlation between serum adiponectin and both dietary fat intake and endotoxin levels. Conclusions: The present results indicate an association between dietary fat intake and endotoxin level, which was highly correlated with a decreased pro-inflammatory state and an improvement in HOMA-IR. In addition, this benefits effect may be associated with an increased adiponectin level, which suggests that the interdisciplinary therapy was effective in improving inflammatory pathways. (AU)

FAPESP's process: 11/50414-0 - Influence of hyperleptinemia on inflammatory and atherogenic responses in obese adolescents
Grantee:Ana Raimunda Dâmaso
Support type: Regular Research Grants