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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antioxidant vitamins C and E supplementation increases markers of haemolysis in sickle cell anaemia patients: a randomized, double-blind, placebo-controlled trial

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Author(s):
Arruda, Martha M. [1] ; Mecabo, Grazielle [1] ; Rodrigues, Celso A. [1] ; Matsuda, Sandra S. [1] ; Rabelo, Iara B. [1] ; Figueiredo, Maria S. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, UNIFESP, Hematol & Blood Transfus Dept, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: British Journal of Haematology; v. 160, n. 5, p. 688-700, MAR 2013.
Web of Science Citations: 12
Abstract

Erythrocytes from sickle cell anaemia (SCA) patients continuously produce larger amounts of pro-oxidants than normal cells. Oxidative stress seems to primarily affect the membrane and results in haemolysis. The use of antioxidants in vitro reduces the generation of pro-oxidants. To evaluate the impact of vitamins C (VitC) and E (VitE) supplementation in SCA patients, patients over 18years were randomly assigned to receive VitC 1400mg+VitE 800mg per day or placebo orally for 180d. Eighty-three patients were enrolled (44 vitamins, 39 placebo), median age 27 (1868) years, 64% female. There were no significant differences between the two groups regarding clinical complications or baseline laboratorial tests. Sixty percent of the patients were VitC deficient, 70% were VitE deficient. Supplementation significantly increased serum VitC and E. However, no significant changes in haemoglobin levels were observed, and, unexpectedly, there was a significant increase in haemolytic markers with vitamin supplementation. In conclusion, VitC+VitE supplementation did not improve anaemia and, surprisingly, increased markers of haemolysis in patients with SCA and S-0-thalassaemia. The exact mechanisms to explain this findings and their clinical significance remain to be determined. (AU)

FAPESP's process: 10/02933-6 - Evaluation of the antioxidants Vitamins C and E effects on hemolytic profile of patients with sickle cell disease: a prospective, randomised, double-blind, placebo-controled study
Grantee:Maria Stella Figueiredo
Support Opportunities: Regular Research Grants