| Full text | |
| Author(s): |
Arruda, Martha M.
[1]
;
Mecabo, Grazielle
[1]
;
Rodrigues, Celso A.
[1]
;
Matsuda, Sandra S.
[1]
;
Rabelo, Iara B.
[1]
;
Figueiredo, Maria S.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Fed Sao Paulo, UNIFESP, Hematol & Blood Transfus Dept, Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | British Journal of Haematology; v. 160, n. 5, p. 688-700, MAR 2013. |
| Web of Science Citations: | 12 |
| Abstract | |
Erythrocytes from sickle cell anaemia (SCA) patients continuously produce larger amounts of pro-oxidants than normal cells. Oxidative stress seems to primarily affect the membrane and results in haemolysis. The use of antioxidants in vitro reduces the generation of pro-oxidants. To evaluate the impact of vitamins C (VitC) and E (VitE) supplementation in SCA patients, patients over 18years were randomly assigned to receive VitC 1400mg+VitE 800mg per day or placebo orally for 180d. Eighty-three patients were enrolled (44 vitamins, 39 placebo), median age 27 (1868) years, 64% female. There were no significant differences between the two groups regarding clinical complications or baseline laboratorial tests. Sixty percent of the patients were VitC deficient, 70% were VitE deficient. Supplementation significantly increased serum VitC and E. However, no significant changes in haemoglobin levels were observed, and, unexpectedly, there was a significant increase in haemolytic markers with vitamin supplementation. In conclusion, VitC+VitE supplementation did not improve anaemia and, surprisingly, increased markers of haemolysis in patients with SCA and S-0-thalassaemia. The exact mechanisms to explain this findings and their clinical significance remain to be determined. (AU) | |
| FAPESP's process: | 10/02933-6 - Evaluation of the antioxidants Vitamins C and E effects on hemolytic profile of patients with sickle cell disease: a prospective, randomised, double-blind, placebo-controled study |
| Grantee: | Maria Stella Figueiredo |
| Support Opportunities: | Regular Research Grants |