Effectiveness of a dietary intervention program on the disease activity, metabolic profile and oxidative stress in patients with psoriatic arthritis and psoriasis activity: a clinical, randomized, placebo-controlled study

• Grant number: 12/18701-2
• Support Opportunities: Regular Research Grants
• Start date: March 01, 2013
• End date: February 28, 2015
• Field of knowledge: Health Sciences - Nutrition - Nutritional Analysis of Population
• Principal Investigator: Marcelo de Medeiros Pinheiro
• Grantee: Marcelo de Medeiros Pinheiro
• Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
• Associated researchers: Beatriz Figueiredo Leite ; Nágila Raquel Teixeira Damasceno ; Patrícia de Souza Genaro

Abstract

Psoriasis (Ps) and psoriatic arthritis (PA) are associated with increased risk of metabolic syndrome (MetS), adiposity and cardiovascular mortality. In all these conditions there is an increase of oxidative stress and inflammation is recognized as one of the mechanisms involved. However, little is known about the influence of diet and micronutrients in these diseases. Objectives: To evaluate the effectiveness of a dietary intervention on disease activity, metabolic profile and oxidative stress in patients with Ps and AP. Patients and methods: We will include 97 patients with Ps and 97 patients with AP, through clinical trial, randomized, placebo-controlled 12-week intervention. Each stage of disease (Ps and PA) will be randomized at a ratio of 1:1:1 into three groups: GD (diet alone), GDS (diet and supplementation of fish oil) and GP (placebo). Patients with liver, lung and kidney diseases are excluded, as were those in nutritional treatment or use of anabolic drugs and consumption of protein supplements, vitamins or antioxidants. The characteristics of the disease and risk factors for MetS, as well as details of concomitant diseases and medications associated will be evaluated by a standard questionnaire. Will be assessed dietary intake, anthropometric data and physical activity. The body composition will be evaluated by absorptiometry total body by dual energy x-ray absorptiometry (DXA, GE-Lunar DPX-MD +). The activity and disease severity will be evaluated using the PASI (Psoriasis Area Severity Index), DAS28-CRP (Disease Activity Score) and HAQ (Health Assessment Questionnaire). In addition, the biochemical evaluation include anti-LDL and anti-LDLoxidada, insulin, apolipoprotein A and B, adiponectin, malondialdehyde and conjugated dienes, oxidative DNA damage and soluble RAGE. Evaluations are made at two points (baseline and 12 weeks). For statistical analysis, will be used mean and standard deviation, Kolmogorov-Smirnov test, Student's t test, Pearson correlation, chi-square or Fisher's exact test and ANOVA. The intention to treat analysis will be used for final data analysis. The value of significance is p <0.05. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LEITE, BEATRIZ FIGUEIREDO; MORIMOTO, MELISSA APARECIDA; GOMES, CARINA; DE CARVALHO KLEMZ, BARBARA NASCIMENTO; GENARO, PATRICIA DE SOUZA; TEIXEIRA DAMASCENO, NAGILA RAQUEL; SZEJNFELD, VERA LUCIA; PINHEIRO, MARCELO DE MEDEIROS. Higher bodily adiposity, fat intake, and cholesterol serum levels are associated with higher disease activity in psoriatic arthritis patients: is there a link among fat and skin and joint involvement?. LIPIDS IN HEALTH AND DISEASE, v. 19, n. 1, FEB 7 2020. (12/18789-7, 12/18701-2)

LEITE, BEATRIZ F.; MORIMOTO, MELISSA A.; GOMES, CARINA M. F.; KLEMZ, BARBARA N. C.; GENARO, PATRICIA S.; SHIVAPPA, NITTIN; HEBERT, JAMES R.; DAMASCENO, NAGILA R. T.; PINHEIRO, MARCELO M.. Dietetic intervention in psoriatic arthritis: the DIETA trial. ADVANCES IN RHEUMATOLOGY, v. 62, n. 1, p. 12-pg., 2022-04-06. (12/18789-7, 12/18701-2)