Square-wave voltammetric determination of bezafibrate in pharmaceutical formulations using a cathodically pretreated boron-doped diamond electrode

Author(s)

Ardila, Jorge Armando ^[1] ; Sartori, Elen Romao ^{[1, 2]} ; Rocha-Filho, Romeu C. ^[1] ; Fatibello-Filho, Orlando ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil

^[2] Univ Estadual Londrina, Dept Quim, BR-86051990 Londrina, PR - Brazil

• Document type: Journal article
• Source: Talanta; v. 103, p. 201-206, JAN 15 2013.
• Web of Science Citations: 37

Abstract

The determination of bezafibrate (BZF) using square-wave voltammetry (SWV) and a cathodically pretreated boron-doped diamond electrode is proposed. Cyclic voltammetry results showed one irreversible oxidation peak for BZF at 1.20 V (vs. Ag/AgCl (3.0 mol L-1 KCl)) in a 0.04 mol L-1 Britton-Robinson (BR) buffer solution (pH 2.0). Under optimized SWV conditions, a linear analytical curve is obtained for the BZF concentration range 0.10-9.1 mu mol L-1 in the BR buffer solution (pH 2.0), with a detection limit of 0.098 mu mol L-1. The obtained recoveries range from 93.4 to 108%. The proposed novel method was successfully applied in the determination of the BZF content in several pharmaceutical formulations (tablets) and the results are in close agreement (at a 95% confidence level) with those obtained using a comparative spectrophotometric method. (C) 2012 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 09/14454-8 - Modified carbon electrodes with carbon nanotubes and/or metallic nanoparticles in chitosan film for determination of sulphur compounds in petroleum derivatives and food
• Grantee: Elen Julciléia Romão Sartori
• Support Opportunities: Scholarships in Brazil - Post-Doctoral