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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanoencapsulation and Characterization of Zidovudine on Poly(L-lactide) and Poly(L-lactide)-Poly(ethylene glycol)-Blend Nanoparticles

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Author(s):
Mainardes, Rubiana Mara [1] ; Daflon Gremiao, Maria Palmira [2]
Total Authors: 2
Affiliation:
[1] Univ Estadual Ctr Oeste UNICENTRO, Dept Farm, BR-85040080 Guarapuava, PR - Brazil
[2] Univ Estadual Paulista, Julio Mesquita Filho UNESP, Fac Ciencias Farmaceut, Dept Farm & Med, BR-14801902 Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Nanoscience and Nanotechnology; v. 12, n. 11, p. 8513-8521, NOV 2012.
Web of Science Citations: 14
Abstract

In this work, the antiretroviral zidovudine was encapsulated on biodegradable poly(L-lactide) (PLA) or poly(L-lactide)-poly(ethylene glycol) (PLA-PEG)-blend nanoparticles by the double-emulsion solvent-evaporation method. The PLA-PEG blend was obtained by the physical mixture of the isolated polymers in organic solvent, whose PEG content ranges from 5 to 50 g in the blends. The physicochemical characteristics of the nanoparticles were evaluated applying particle-size and zeta-potential analyses, scanning electron microscopy, differential scanning calorimetry and Fourier-transform infrared spectroscopy. The release rate of zidovudine from the nanoparticles was investigated as well. The drug encapsulation efficiencies were around 50%, and the mean diameters of the nanoparticles were less than 400 nm. The PEG presence influenced all of the analyzed physicochemical parameters. The amount of drug released increases with the PEG presence in the blend. Therefore, the investigated nanoparticles are very promising carriers for zidovudine. (AU)