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Bioadhesive nanostructured systems for intraductal administration and localized treatment of Breast Cancer

Grant number: 20/01208-8
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): March 01, 2020
Effective date (End): February 29, 2024
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal researcher:Luciana Biagini Lopes
Grantee:Julia Sapienza Passos
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors, AP.JP2

Abstract

Breast Tumors have a high incidence worldwide, but there are a lack of effective and well-accepted alternatives for localized treatment of noninvasive forms of the disease, such as the Ductal Carcinoma In Situ (DCIS). In this project, we propose the development of polyelectrolyte nanoparticles for intraductal administration of cytotoxic drugs, in order to optimize the drug localization in breast tissue. These complexes will be developed using chitosan and hyaluronic acid, and incorporated into Poloxamer 407, a thermosensitive polymer, in order to obtain in vivo gelling systems, aiming to prolong the residence time of nanoparticles in the mammary ducts. The affinity between composition and drug incorporation will be studied in order to evaluate how composition affects the properties of the system, by characterization by particle size, polydispersion index and zeta potential. A formulation will then be selected (optimized formulation) to evaluate the bioadhesive properties, irritation potential, drug release and time of residence in the breast tissue. The influence of nanoencapsulation on its efficacy and selectivity will be evaluated on 2D tumor cultures and on 3D multicellular spheroids, by studying formulation influence on viability and proliferation of tumor and non-transformed cells. With this study, we aim to contribute to the development of a more effective and safe platform for the treatment of DCIS. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MOJEIKO, GABRIELA; PASSOS, JULIA SAPIENZA; APOLINARIO, ALEXSANDRA CONCEICAO; LOPES, LUCIANA BIAGINI. Topical transdermal chemoprevention of breast cancer: where will nanomedical approaches deliver us?. Nanomedicine, JUL 2021. Web of Science Citations: 0.
GIACONE, V, DANIELA; DARTORA, VANESSA F. M. C.; DE MATOS, JENYFFER K. R.; PASSOS, JULIA S.; MIRANDA, DANIEL A. G.; DE OLIVEIRA, ERICA A.; SILVEIRA, EDILBERTO R.; COSTA-LOTUFO, V, LETICIA; MARIA-ENGLER, SILVYA S.; LOPES, LUCIANA B. Effect of nanoemulsion modification with chitosan and sodium alginate on the topical delivery and efficacy of the cytotoxic agent piplartine in 2D and 3D skin cancer models. International Journal of Biological Macromolecules, v. 165, n. A, p. 1055-1065, DEC 15 2020. Web of Science Citations: 2.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.