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Development and application of multifunctional nanocarriers for intraductal delivery of chemotherapy aiming at Breast Cancer treatment

Grant number: 19/26048-6
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): June 01, 2020
Field of knowledge:Health Sciences - Pharmacy - Pharmaceutical Technology
Principal Investigator:Luciana Biagini Lopes
Grantee:Giovanna Cassone Salata
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:18/13877-1 - Nanocarriers for localized treatment and chemoprevention of breast tumors, AP.JP2
Associated scholarship(s):22/07303-8 - Development and efficacy of a lipid nanocarrier loaded with mRNA intended for transient CAR-T response in acute lymphoblastic leukemia treatment, BE.EP.DR


In this project, we propose the development and evaluation of nanoemulsions functionalized with hyaluronic acid for localized intraductal treatment of Ductal Carcinoma In Situ and other breast lesions (which increase the risk for development of invasive forms of Breast Cancer) combining efficacy, selectivity and reduction of systemic adverse effects of chemotherapy. In order to potentialize the cytotoxic effects and reduce resistance, we propose the co-incorporation of 3 active compounds: (i) paclitaxel, a cytotoxic agent, effective in various types of tumors, (ii) elacridar, a potent inhibitor of efflux transporter P-gp, associated with the development of resistance to chemotherapy (including paclitaxel) and (iii) perillyl alcohol, a monoterpene capable of potentializing the cytotoxic effect of other compounds. After nanoemulsion obtainment and characterization, we will assess the cellular effects and application of the nanocarriers in 2D and 3D models, cell uptake, mammary retention and efficacy in an animal model of chemically induced carcinogenesis. With this project, we aim to contribute to the development of a localized, more effective and safer platform for Breast Cancer treatment. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
COSTA-FERNANDEZ, SANDRA; MATOS, JENYFFER K. R.; SCHEUNEMANN, GABY S.; SALATA, GIOVANNA C.; CHORILLI, MARLUS; WATANABE, IL-SEI; DE ARAUJO, GABRIEL L. B.; SANTOS, MARINILCE F.; ISHIDA, KELLY; LOPES, LUCIANA B.. Nanostructured lipid carriers containing chitosan or sodium alginate for co-encapsulation of antioxidants and an antimicrobial agent for potential application in wound healing. International Journal of Biological Macromolecules, v. 183, p. 668-680, . (14/50928-2, 19/26048-6, 13/16617-7, 15/07993-0, 17/19374-9, 18/13877-1)

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