Polymorphisms in the 5-HTR2A gene related to obstructive sleep apnea syndrome

Author(s)

Vânia Belintani Piatto ^[1] ; Thiago Bittencourt Ottoni de Carvalho ^[2] ; Nely Silva Aragão De Marchi ^[3] ; Fernando Drimel Molina ^[4] ; José Victor Maniglia ^[5]

Affiliation

^[1] FAMERP. Otorhinolaryngology and Head & Neck Surgery Department

^[2] FAMERP. Otorhinolaryngology and Head & Neck Surgery Department

^[3] FAMERP. FUNFARME. Sleep Ambulatory Unit

^[4] FAMERP. FUNFARME. Otorhinolaryngology and Head & Neck Surgery Outpatient Unit

^[5] FAMERP. Otorhinolaryngology and Head & Neck Surgery Department

• Document type: Journal article
• Source: Brazilian Journal of Otorhinolaryngology; v. 77, n. 3, p. 348-355, 2011-06-00.

Abstract

Obstructive sleep apnea syndrome (OSAS) is one of the most complex disorders of sleep; it involves several genetic factors that contribute to the phenotype. Serotonin (5-HT) regulates a variety of visceral and physiological functions, including sleep. Gene 5-HTR2A polymorphisms may change the transcription of several receptors in the serotoninergic system, thereby contributing to OSAS. AIM: To investigate the prevalence of T102C and -1438G/A polymorphisms in the 5-HTR2A gene of patients with and without OSAS . MATERIAL AND METHOD: A molecular study of 100 index-cases and 100 controls of both genders. DNA was extracted from blood leukocytes samples and the regions that enclose both polymorphisms were amplified with PCR-RFLP. STUDY DESIGN: A cross-sectional case study. RESULTS: There was a significant prevalence of males in index cases compared to controls (p<0.0001). No significant genotypic differences between cases and controls were found in T102C polymorphisms (p=1.000).There were significant differences between the AA genotype of -1438G/A polymorphisms and patients with OSAS (OR:2.3; CI95%:1.20-4.38, p=0.01). CONCLUSION: Serotonergic mechanisms may be related to OSAS. There were no differences in the prevalence of T102C polymorphisms in patients with OSAS and the control group. There is evidence of an association between the -1438G /A polymorphism and OSAS. (AU)

• FAPESP's process: 08/01070-4 - Identification of polymorphisms in HTR2A gene related to obstructive sleep apnea syndrome
• Grantee: Vânia Belintani Piatto
• Support Opportunities: Regular Research Grants