| Full text | |
| Author(s): |
Rayne Borges Torres
[1]
;
Renato Giuseppe Giovanni Terzi
[2]
;
Antônio Luís Eiras Falcão
;
Nelci Fenalti Höehr
[4]
;
Venâncio Pereira Dantas Filho
[5]
Total Authors: 5
|
| Affiliation: | [1] Faculdades Integradas de Patos - Brasil
[2] UNICAMP. FCM
[4] UNICAMP. FCM. Clinical Pathology Department
[5] UNICAMP. FCM
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | Arquivos de Neuro-Psiquiatria; v. 65, p. 739-744, 2007-09-00. |
| Abstract | |
INTRODUCTION: The concentration of 2,3-diphosphoglycerate (2,3-DPG/Hct) increases as a physiological occurrence to pH increase and hyperventilation. This response was tested in patients with severe traumatic brain injury (TBI). METHOD: The concentration of 2,3-DPG/Hct was measured daily for six days in eleven patients with severe TBI in need of optimized hyperventilation because of intracranial hypertension. RESULTS:There was correlation between pH and the concentration of DPG/Hct. The concentration of 2,3-DPG/Hct remained predominantly within normal levels with slight increase in the sixth day of the study. The concentration of 2,3-DPG/Hct correlated significantly with measured partial pressure of oxygen that saturates 50% the hemoglobin of the blood (P50st), confirming the consistency of our data. CONCLUSION: The expected physiological response of a progressive increase in concentration of 2,3-DPG/Hct to hyperventilation was not observed. This fact may be explained by the intermittent and not sustained hyperventilation as dictated by the protocol of optimized ventilation. (AU) | |