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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Psychophysical measurements of luminance and chromatic spatial and temporal contrast sensitivity in Duchenne muscular dystrophy

Full text
Author(s):
Marcelo Fernandes Costa [1] ; Mirella Telles Salgueiro Barboni [2] ; Dora Fix Ventura [3]
Total Authors: 3
Affiliation:
[1] Universidade de São Paulo - Brasil
[2] Universidade de São Paulo - Brasil
[3] Universidade de São Paulo - Brasil
Total Affiliations: 3
Document type: Journal article
Source: Psychology & Neuroscience; v. 4, n. 1, p. 67-74, 2011-06-00.
Abstract

In children with Duchenne muscular dystrophy, color vision losses have been related to dystrophin deletions downstream of exon 30, which affect a dystrophin isoform, Dp260, present in the retina. To further evaluate visual function in DMD children, we measured spatial, temporal, and chromatic red-green and blue-yellow contrast sensitivity in two groups of DMD children with gene deletion downstream and upstream of exon 30. Psychophysical spatial contrast sensitivity was measured for low, middle, and high spatial frequencies with achromatic gratings and for low and middle frequencies with red-green and blue-yellow chromatic gratings. Temporal contrast sensitivity was also measured with achromatic stimuli. A reduction in sensitivity at all spatial luminance contrasts was found for the DMD patients with deletion downstream of exon 30. Similar results were found for temporal luminance contrast sensitivity. Red-green chromatic contrast sensitivity was reduced in DMD children with deletion downstream of exon 30, whereas blue-yellow chromatic contrast sensitivity showed no significant differences. We conclude that visual function is impaired in DMD children. Furthermore, we report a genotype-phenotype relationship because the visual impairment occurred in children with deletion downstream but not upstream of exon 30, affecting the retinal isoform of dystrophin Dp260. (AU)

FAPESP's process: 07/55125-1 - Electrophysiological and psychophysical evaluation of ON and OFF visual pathways in Duchenne muscular dystrophy young patients
Grantee:Mirella Telles Salgueiro Barboni
Support Opportunities: Scholarships in Brazil - Doctorate