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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Electrospray ionization mass spectrometry screening of piperidine alkaloids from Senna spectabilis (Fabaceae) extracts: fast identification of new constituents and co-metabolites

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Author(s):
Marcos Pivatto [1] ; Antônio E. M. Crotti [2] ; Norberto P. Lopes [3] ; Ian Castro-Gamboa [4] ; Amanda de Rezende [5] ; Cláudio Viegas Jr. [6] ; Maria Claudia M. Young [7] ; Maysa Furlan [8] ; Vanderlan S. Bolzani [9]
Total Authors: 9
Affiliation:
[1] Universidade Estadual Paulista. Instituto de Química - Brasil
[2] Universidade de Franca. Núcleo de Pesquisas em Ciências Exatas e Tecnológicas - Brasil
[3] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas. Departamento de Física e Química - Brasil
[4] Universidade Estadual Paulista. Instituto de Química - Brasil
[5] Universidade Estadual Paulista. Instituto de Química - Brasil
[6] Universidade Estadual Paulista. Instituto de Química - Brasil
[7] Instituto de Botânica. Seção de Fisiologia e Bioquímica de Plantas - Brasil
[8] Universidade Estadual Paulista. Instituto de Química - Brasil
[9] Universidade Estadual Paulista. Instituto de Química - Brasil
Total Affiliations: 9
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 16, p. 1431-1438, 2005-11-00.
Field of knowledge: Physical Sciences and Mathematics - Chemistry
Abstract

The fragmentation pattern of a homologous series of piperidine alkaloids isolated from S. spectabilis was investigated using electrospray ionization tandem mass spectrometry (ESI-MS/MS). The ESI-MS and ESI-MS/MS analyses of EtOH extracts and fractions from flowers and fruits of S. spectabilis allowed to elucidate the structures of four new compounds. The identification of these co-metabolites, based on the fragmentation patterns of previously isolated compounds, and further confirmed by accurate mass spectrometry defines this technique as a powerful tool to determine the "metabolomic profile" of species which has pharmacological importance. (AU)

FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
Grantee:Vanderlan da Silva Bolzani
Support Opportunities: BIOTA-FAPESP Program - Thematic Grants