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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinicopathological and immunohistochemical analysis of 19 cases of oral eosinophilic ulcers

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Author(s):
Fonseca, Felipe Paiva [1] ; Benevenuto de Andrade, Bruno Augusto [1] ; Coletta, Ricardo D. [1] ; Vargas, Pablo Agustin [1] ; Lopes, Marcio Ajudarte [1] ; de Almeida, Oslei Paes [1] ; Santos-Silva, Alan Roger [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Piracicaba Dent Sch, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY; v. 115, n. 4, p. 532-540, APR 2013.
Web of Science Citations: 4
Abstract

Objective. The aim of this study was to describe the clinicopathological and immunohistochemical features of 19 cases of oral eosinophilic ulcers and discuss the hypothesis that this entity could represent a spectrum of the CD30(+) lymphoproliferative disorder. Material and Methods. Clinical data concerning gender, age, affected site, and clinical presentation of 19 patients were collected and a broad immunohistochemical panel was carried out. Eosinophil distribution in relation to muscular tissue was evaluated using an Aperio ScanScope CS scanner. Results. The mean age of the patients was 58.6 years, with a male preponderance. A single painful ulcer in the tongue was the most common clinical presentation. There was no predilection of eosinophils for surrounding muscular fibers because this population was equally distributed in areas adjacent to and distant from these structures. The inflammatory infiltrate was mainly formed by cytotoxic T lymphocytes and CD30 expression was not limited to large atypical cells; it also stained small reactive lymphocytes. Conclusions. Considering the clinical, histopathological, and immunohistochemical characteristics, oral eosinophilic ulcers must be considered a self-limiting reactive condition. (Oral Surg Oral Med Oral Pathol Oral Radiol 2013;115:532-540) (AU)

FAPESP's process: 09/53839-2 - Creation of a Digital Pathology Laboratory using a histological slidescanner
Grantee:Oslei Paes de Almeida
Support Opportunities: Multi-user Equipment Program