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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aluminum concentrations in central and peripheral areas of malignant breast lesions do not differ from those in normal breast tissues

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Author(s):
Rodrigues-Peres, Raquel Mary [1] ; Cadore, Solange [2] ; Febraio, Stefanny [2] ; Heinrich, Juliana Karina [1] ; Serra, Katia Piton [1] ; Derchain, Sophie F. M. [1] ; Vassallo, Jose [3] ; Sarian, Luis Otavio [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci, Dept Obstet & Gynecol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, Inst Chem, Dept Analyt Chem, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Fac Med Sci, Dept Pathol, Campinas, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: BMC CANCER; v. 13, MAR 8 2013.
Web of Science Citations: 9
Abstract

Background: Aluminum is used in a wide range of applications and is a potential environmental hazard. The known genotoxic effects of aluminum might play a role in the development of breast cancer. However, the data currently available on the subject are not sufficient to establish a causal relationship between aluminum exposure and the augmented risk of developing breast cancer. To achieve maximum sensitivity and specificity in the determination of aluminum levels, we have developed a detection protocol using graphite furnace atomic absorption spectrometry (GFAAS). The objective of the present study was to compare the aluminum levels in the central and peripheral areas of breast carcinomas with those in the adjacent normal breast tissues, and to identify patient and/or tumor characteristics associated with these aluminum levels. Methods: A total of 176 patients with breast cancer were included in the study. Samples from the central and peripheral areas of their tumors were obtained, as well as from the surrounding normal breast tissue. Aluminum quantification was performed using GFAAS. Results: The average (mean +/- SD) aluminum concentrations were as follows: central area, 1.88 +/- 3.60 mg/kg; peripheral area, 2.10 +/- 5.67 mg/kg; and normal area, 1.68 +/- 11.1 mg/kg. Overall and two-by-two comparisons of the aluminum concentrations in these areas indicated no significant differences. We detected a positive relationship between aluminum levels in the peripheral areas of the tumors, age and menopausal status of the patients (P = .02). Conclusions: Using a sensitive quantification technique we detected similar aluminum concentrations in the central and peripheral regions of breast tumors, and in normal tissues. In addition, we did not detect significant differences in aluminum concentrations as related to the location of the breast tumor within the breast, or to other relevant tumor features such as stage, size and steroid receptor status. The next logical step is the assessment of whether the aluminum concentration is related to the key genomic abnormalities associated with breast carcinogenesis. (AU)

FAPESP's process: 08/02469-8 - Genomic instability in breast malignant tumors as related to the concentration of intracelular aluminium and to estrogen receptor status
Grantee:Luís Otávio Zanatta Sarian
Support Opportunities: Regular Research Grants
FAPESP's process: 09/06148-4 - Genomic instability in breast malignant tumors as related to the concentration of intracelular aluminium and to estrogen receptor status
Grantee:Raquel Mary Rodrigues Peres
Support Opportunities: Scholarships in Brazil - Doctorate