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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Enhanced nicotine-seeking behavior following pre-exposure to repeated cocaine is accompanied by changes in BDNF in the nucleus accumbens of rats

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Author(s):
Leao, Rodrigo M. [1, 2] ; Cruz, Fabio C. [1] ; Carneiro-de-Oliveira, Paulo E. [1, 2] ; Rossetto, Daniella B. [3] ; Valentini, Sandro R. [3] ; Zanelli, Cleslei F. [3] ; Planeta, Cleopatra S. [1, 2]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista UNESP, Pharmacol Lab, Sch Pharmaceut Sci, BR-14801902 Sao Paulo - Brazil
[2] Joint Grad Program Physiol Sci UFSCar UNESP, Sao Paulo - Brazil
[3] UNESP Univ Estadual Paulista, Dept Biol Sci, Sch Pharmaceut Sci, Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Pharmacology Biochemistry and Behavior; v. 104, p. 169-176, MAR 2013.
Web of Science Citations: 7
Abstract

We investigated the behavioral and molecular interactions between cocaine and nicotine, through evaluating locomotor activity, nicotine intravenous self-administration and gene expression. Locomotor sensitization was induced in male Wistar rats by repeated cocaine (20 mg/kg; i.p.) or saline injections once a day over 7 days. Three days after the last injection, rats were challenged with either saline or cocaine (15 mg/kg; i.p.) and the locomotor activity was measured. The very next day animals received either saline or nicotine (0.4 mg/kg; s.c.) and the locomotor cross-sensitization was tested. Animals were then prepared with intrajugular catheters for nicotine self-administration. Nicotine self-administration patterns were evaluated using fixed or progressive ratio schedules of reinforcement and a 24-h unlimited access binge. Immediately after the binge sessions animals were decapitated, the brains were removed and the nucleus accumbens was dissected. The dynorphin (DYN), mu-opioid receptor (mu opioid), neuropeptide Y (NPY), brain-derived neurotrophic factor (BDNF), tropomyosin-related tyrosine kinase B receptor (TrkB) and corticotropin-releasing factor receptor type 1 (CRF-R1) gene expression were measured by the reverse transcription-polymerase chain reaction (RT-PCR). Pretreatment with cocaine caused sensitization of cocaine motor response and locomotor cross-sensitization with nicotine. In the self-administration experiments repeated cocaine administration caused an increase in the nicotine break point and nicotine intake during a 24 h binge session. (C) 2013 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/07469-9 - Ethanol and nicotine interaction along ontogeny: changes in self-administration parameters and gene expression in the mesolimbic system
Grantee:Cleopatra da Silva Planeta
Support Opportunities: Regular Research Grants
FAPESP's process: 08/10691-2 - Stress and nicotine self-administration: involvement of CREB, PKA and ERK transduction pathway in the nucleus accumbens and pre-frontal cortex
Grantee:Rodrigo Molini Leão
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)