| Full text | |
| Author(s): |
Ferrari, Renata
[1]
;
Tanni, Suzana E.
[1]
;
Caram, Laura M. O.
[1]
;
Correa, Corina
[1]
;
Correa, Camila R.
[1]
;
Godoy, Irma
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Estadual Paulista, Fac Med Botucatu, UNESP, Disciplina Pneumol, Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | RESPIRATORY RESEARCH; v. 14, FEB 20 2013. |
| Web of Science Citations: | 45 |
| Abstract | |
Background: Past studies have shown that mean values of Interleukin-6 (IL-6) and C-reactive protein (CRP) do not change significantly in COPD patients over a one-year period. However, longer period follow-up studies are still lacking. Thus, the aim of this study is to evaluate plasma CRP and IL-6 concentration over three years in COPD patients and to test the association between these inflammatory mediators and disease outcome markers. Methods: A cohort of 77 outpatients with stable COPD was evaluated at baseline, and 53 (mean FEV1, 56% predicted) were included in the prospective study. We evaluated Interleukin-6 (IL-6), C-reactive protein (CRP), six-minute walking distance (6MWD), and body mass index (BMI) at baseline and after three years. Plasma concentration of IL-6 was measured by high sensitivity ELISA, and CRP was obtained by high sensitivity particle-enhanced immunonephelometry. Results: IL-6 increased significantly after 3 years compared to baseline measurements {[}0.8 (0.5-1.3) vs 2.4 (1.3-4.4) pg/ml; p < 0.001] and was associated with worse 6MWD performance. In the Cox regression, increased IL-6 at baseline was associated with mortality {[}Hazard Ratio (95% CI) = 2.68 (0.13, 1.84); p = 0.02]. CRP mean values did not change {[}5 (1.6-7.9) vs 4.7 (1.7-10) pg/L; p = 0.84], although eleven patients (21%) presented with changes >3 mg/L in CRP after 3 years. Conclusions: The systemic inflammatory process, evaluated by IL-6, seems to be persistent, progressive and associated with mortality and worse physical performance in COPD patients. (AU) | |
| FAPESP's process: | 10/08557-6 - Follow-up study of inflammatory markers in COPD patients in a three years period |
| Grantee: | Renata Ferrari |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 10/08527-0 - Follow-up study of inflammatory markers in COPD patients over three years period |
| Grantee: | Irma de Godoy |
| Support Opportunities: | Regular Research Grants |