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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Heteropterys tomentosa (A. Juss.) infusion counteracts Cyclosporin a side effects on the ventral prostate

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Author(s):
Freitas, Karine M. [1] ; Monteiro, Juliana C. [2] ; Gomes, Marcos L. M. [3] ; Taboga, Sebastiao R. [4] ; Dolder, Heidi [1]
Total Authors: 5
Affiliation:
[1] State Univ Campinas IB UNICAMP, Dept Struct & Funct Biol, Inst Biol, BR-13083863 Campinas, SP - Brazil
[2] Univ Fed Espirito Santo, CEUNES, Dept Agr & Biol Sci, Sao Mateus - Brazil
[3] Univ Fed Espirito Santo, CEUNES, Dept Hlth Sci, Sao Mateus - Brazil
[4] State Univ Sao Paulo Julio de Mesquita Filho, Inst Biosci Language & Sci, Dept Biol, Sao Jose Do Rio Preto - Brazil
Total Affiliations: 4
Document type: Journal article
Source: BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE; v. 13, FEB 13 2013.
Web of Science Citations: 5
Abstract

Background: Cyclosporin A (CsA) is an immunosuppressive drug widely used in treatment of auto-immune diseases or after organ transplants. However, several side effects are commonly associated with CsA long term intake, some regarding to loss of reproductive organ function due to oxidative damage. Considering that phytotherapy is an important tool often used against oxidative stress, we would like to describe the beneficial effects of Heteropterys tomentosa intake to minimize the damage caused by CsA to the ventral prostate tissue of Wistar rats under laboratorial conditions. Methods: Thirty adult Wistar rats (Rattus norvegicus albinus) were divided into: control group (water); CsA group (Cyclosporin A); Ht group (H. tomentosa infusion) and CsA + Ht group (CsA and H. tomentosa infusion). Plasmic levels of hepatotoxicity markers, triglycerides, cholesterol and glucose were quantified. The ventral prostate tissue was analyzed under light microscopy, using stereological, morphometrical and immunohistochemical techniques. Results: H. tomentosa did not cause any alterations either of the plasmic parameters or of the ventral prostate structure. CsA caused alterations of GOT, total and indirect bilirubin, cholesterol, triglycerides and glucose levels in the plasma; CsA-treated rats showed alterations of the ventral prostate tissue. There were no alterations regarding the plasma levels of GOT, triglycerides and glucose of CsA + Ht animals. The same group also showed normalization of most of the parameters analyzed on the ventral prostate tissue when compared to the CsA group. The treatments did not alter the pattern of AR expression or the apoptotic index of the ventral prostate epithelium. Conclusions: The results suggest a protective action of the H. tomentosa infusion against the side effects of CsA on the ventral prostate tissue, which could also be observed with plasmic biochemical parameters. (AU)

FAPESP's process: 09/07824-3 - Effect of cyclosporine A associated with "nó-de-cachorro" infusion (Heteropterys aphrodisiaca, O. Mach, 1949) on the prostate of Wistar rats
Grantee:Karine Moura de Freitas
Support Opportunities: Scholarships in Brazil - Master