(-)-7-hydroxycassine: a new 2,6-dialkylpiperidin-3-ol alkaloid and other constituents isolated from flowers and fruits of Senna spectabilis (Fabaceae)

Author(s)

Viegas Junior, Claudio ^[1] ; Pivatto, Marcos ^[2] ; de Rezende, Amanda ^[3] ; Hamerski, Lidilhone ^[3] ; Siqueira Silva, Dulce Helena ^[3] ; da Silva Bolzani, Vanderlan ^[3]

Affiliation

^[1] Univ Fed Alfenas, Inst Chem, Phytochem & Med Chem Lab LFQM, BR-37130000 Alfenas, MG - Brazil

^[2] Univ Fed Uberlandia, Inst Chem, BR-38400902 Uberlandia, MG - Brazil

^[3] Sao Paulo State Univ UNESP Julio de Mesquita Filh, Inst Chem, Dept Organ Chem, Nucleus Bioassays Biosynth & Ecophysiol Nat Prod, BR-14801970 Araraquara, SP - Brazil

• Document type: Journal article
• Source: Journal of the Brazilian Chemical Society; v. 24, n. 2, p. 230-235, FEB 2013.
• Web of Science Citations: 2

Abstract

The phytochemical study of flowers and green fruits of Senna spectabilis furnished a new substituted 2,6-dialkylpiperidin-3-ol alkaloid, named (-)-7-hydroxycassine, along with five known piperidine alkaloids: (-)-cassine, (-)-spectaline, (-)-3-O-acetylspectaline, (-)-7-hydroxyspectaline and (-)-iso-6-spectaline. In addition to non-alkaloidal, chemical constituents from other chemical classes were also identified, including the steroid β-sitosterol, the flavonoids luteolin and 3-methoxyluteolin, the triterpene betulinic acid and trans-cinnamic acid. To our knowledge, compounds are being reported for the first time in this species. (AU)

• FAPESP's process: 03/02176-7 - Conservation and sustainable use of the diversity from Cerrado and Atlantic Forest: chemical diversity and prospecting for potential drugs - phase II
• Grantee: Vanderlan da Silva Bolzani
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants