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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Oxacillin Resistance and Antimicrobial Susceptibility Profile of Staphylococcus saprophyticus and Other Staphylococci Isolated from Patients with Urinary Tract Infection

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Author(s):
Ferreira, Adriano M. [1, 2] ; Bonesso, Mariana F. [1, 2] ; Mondelli, Alessandro L. [3] ; Camargo, Carlos H. [3] ; Cunha, Maria de Lourdes R. S. [1, 2]
Total Authors: 5
Affiliation:
[1] UNESP Univ Estadual Paulista, Botucatu Biosci Inst, Dept Microbiol & Imunol, BR-18618970 Botucatu, SP - Brazil
[2] UNESP Univ Estadual Paulista, Botucatu Sch Med, Dept Trop Med, BR-18618970 Botucatu, SP - Brazil
[3] UNESP Univ Estadual Paulista, Botucatu Sch Med, Dept Internal Med, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Chemotherapy; v. 58, n. 6, p. 482-491, 2012.
Web of Science Citations: 9
Abstract

Background: Staphylococcus saprophyticus is the second most frequent community-acquired causative agent of urinary tract infection (UTI). The objective of this study was to evaluate the susceptibility profile and resistance detection in Staphylococcus species. isolated from patients with UTI. Materials and Methods: The isolates were investigated using the disk diffusion method, Vitek I system, E-test (R), and detection of the mecA gene. Results: Most isolates (76.2%) were resistant to oxacillin by the disk diffusion method, followed by those resistant to penicillin (72.2%). The oxacillin disk diffusion method, E-test, and Vitek I method showed higher sensitivity (94.4%) and lower specificity (28.9, 26.5, and 24.0%, respectively) than the cefoxitin disk diffusion test (sensitivity: 83.5%, specificity: 85.5%) for the detection of oxacillin resistance. Conclusions: The large number of oxacillin-resistant isolates indicates that the breakpoint value recommended by the Clinical and Laboratory Standards Institute may overestimate oxacillin resistance in S. saprophyticus. Thus, changes in these guidelines are necessary for the correct detection of this resistance. Copyright (C) 2013 S. Karger AG, Basel (AU)

FAPESP's process: 09/10083-5 - Comparison of methods from identification and profile of sensitivity to antimicrobial in Staphylococcus spp. isolated from patients with urinary tract infection (UTI)
Grantee:Maria de Lourdes Ribeiro de Souza da Cunha
Support Opportunities: Regular Research Grants
FAPESP's process: 12/25108-6 - Oxacillin resistance and antimicrobial susceptibility profile of Staphylococcus saprophyticus and other Staphylococci isolated from patients with urinary tract infection
Grantee:Maria de Lourdes Ribeiro de Souza da Cunha
Support Opportunities: Regular Research Grants - Publications - Scientific article