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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A new approach for the thermodynamic modeling of the solubility of amino acids and beta-lactam compounds as a function of pH

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Author(s):
Mercier Franco, Luis Fernando [1] ; Mattedi, Silvana [2] ; Pessoa Filho, Pedro de Alcantara [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Sch Engn, Dept Chem Engn, Bioproc Engn Grp, BR-05424970 Sao Paulo - Brazil
[2] Univ Fed Bahia, Polytech Sch, Chem Engn Grad Program, BR-41170290 Salvador, BA - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Fluid Phase Equilibria; v. 354, p. 38-46, SEP 25 2013.
Web of Science Citations: 4
Abstract

A new model to describe the solubility of amino acids and beta-lactam compounds as a function of pH is proposed. The description of the solid liquid equilibrium entails simultaneous calculation of phase and chemical equilibria. The liquid-phase non-ideality was accounted for through an extended Pitzer model for polyelectrolyte solutions. A statistical thermodynamic interpretation of Pitzer's binary interaction parameters is also presented. The model was successfully applied to different systems containing amino-acids, as well as glycine and its oligopeptides and beta-lactam compounds such as ampicillin and 6-aminopenicillanic acid. (C) 2013 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/22070-5 - Thermodynamics of protein solutions: experimental determination and modeling of protein-protein interactions
Grantee:Luís Fernando Mercier Franco
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 08/11232-1 - Study on the influence of co-solvents on thermodynamic properties of proteins in solution
Grantee:Pedro de Alcântara Pessôa Filho
Support Opportunities: Regular Research Grants