The Role of Leptinemia State as a Mediator of Inflammation in Obese Adults

Author(s):Show less -

dos Santos Moraes, A. ^{[1, 2]} ; Pisani, L. P. ^{[1, 2, 3]} ; Corgosinho, F. C. ^[3] ; Testa Carvalho, L. O. ^{[1, 2]} ; Masquio, D. C. L. ^{[1, 2]} ; Jamar, G. ^{[1, 2]} ; Sanches, R. B. ^{[1, 2]} ; Oyama, L. M. ^{[1, 2, 3]} ; Damaso, A. R. ^{[4, 1, 2, 3]} ; Belote, C. ^[2] ; Caranti, D. A. ^{[4, 1, 2]}

Affiliation

^[1] Fed Univ Sao Paulo UNIFESP, Post Grad Program Interdisciplinary Hlth Sci, Santos, SP - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Obes Study Grp GEO, Santos, SP - Brazil

^[3] Fed Univ Sao Paulo UNIFESP, Post Grad Program Nutr, Santos, SP - Brazil

^[4] Fed Univ Sao Paulo UNIFESP, Dept Biosci, Santos, SP - Brazil

• Document type: Journal article
• Source: Hormone and Metabolic Research; v. 45, n. 8, p. 605-610, AUG 2013.
• Web of Science Citations: 10

Abstract

Hyperleptinemia has emerged as a marker of proinflammatory status, while the adiponectin/leptin ratio has been used to identify anti-inflammatory state. In this context, the aims of the present study were to investigate the role of leptinemia, adjusted by tertiles, on inflammatory state in obese adults according to obesity degree. This is a cross-sectional study comprised of 43 obese adults. The anthropometric variables and body composition were analyzed, as well as markers of inflammation such as leptin, adiponectin, and plasminogen activator inhibitor. Subjects were grouped using adjusted tertiles of the leptin levels. The major finding was the negative correlation between leptin concentration with adiponectin/leptin ratio (r = -0.622, p = 0.000) and the positive correlation with leptin/adiponectin ratio (r = 0.622, p = 0.000). Indeed, both ratios were decreased and increased, respectively, according to the obesity degree. Furthermore, in the stepwise multiple linear regression analysis, the high degree of obesity was an independent predictor of leptinemia when adjusted for age and BMI (beta = 0.588, p = 0.000 and beta = 0.778, p = 0.005). Finally, the strong negatively correlation between the leptinemia with adiponectin/leptin ratio and the positive correlation with leptin/adiponectin ratio reinforce the role of this adipokine as a biomarker of inflammation in obese adults, according to obesity degree. Our findings can elucidate that hyperleptinemic status was a major factor in the proinflammatory status related to higher obesity degree. All together, these data reinforce the role of leptinemia state as a mediator of inflammation in obese adults. (AU)

• FAPESP's process: 11/51723-7 - Effects of interdisciplinary therapy on metabolic syndrome control in obese adults and its relationship with pro and anti inflammatory adipocytes
• Grantee: Danielle Arisa Caranti
• Support Opportunities: Regular Research Grants