Does Excess Weight Interfere with Bone Mass Accumulation during Adolescence?

Author(s)

Mosca, Luciana Nunes ^[1] ; da Silva, Valeria Nobrega ^[1] ; Lederer Goldberg, Tamara Beres ^[1]

Affiliation

^[1] Sao Paulo State Univ, Postgrad Program Gynecol Obstet & Mastol, Discipline Adolescent Med, Dept Pediat, Botucatu Sch Med, UNESP, BR-18618970 Botucatu, SP - Brazil

• Document type: Review article
• Source: NUTRIENTS; v. 5, n. 6, p. 2047-2061, JUN 2013.
• Web of Science Citations: 23

Abstract

Obesity and osteoporosis are important global health problems characterized by increasing prevalence with high impact on morbidity and mortality. The objective of this review was to determine whether excess weight during adolescence interferes with bone mass accumulation. If bone mineral gain can be optimized during puberty, adults are less likely to suffer from the devastating complications of osteoporosis. The increased fracture risk in obese children has also been attributed to a lower bone mass for weight compared to non-obese children. Thus, adiposity present in this age group may not result in the protection of bone mass, in contrast to what has been observed in adults. However, studies involving adolescents have reported both protective and detrimental effects of obesity on bone. The results and mechanisms of these interactions are controversial and have not been fully elucidated, a fact highlighting the extreme relevance of this topic and the need to monitor intervening and interactive variables. (AU)

• FAPESP's process: 11/05991-0 - The impact of body fat excess on bone densitometry and bone metabolims biomarkers: a study with overweight, obese and superobese adolescents
• Grantee: Tamara Beres Lederer Goldberg
• Support Opportunities: Regular Research Grants