| Full text | |
| Author(s): |
Durigan, Joao L. Q.
[1]
;
Delfino, Gabriel B.
[2]
;
Peviani, Sabrina M.
[2]
;
Russo, Thiago L.
[2]
;
Ramirez, Carolina
[3]
;
DaSilva Gomes, Andre D. B.
[2]
;
Salvini, Tania F.
[2]
Total Authors: 7
|
| Affiliation: | [1] Univ Brasilia, Dept Phys Therapy, BR-70910900 Brasilia, DF - Brazil
[2] Univ Fed Sao Carlos, Dept Phys Therapy, Muscle Plast Lab, Sao Paulo - Brazil
[3] Ind Univ Santander, Sch Phys Therapy, Santander - Colombia
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | MUSCLE & NERVE; v. 49, n. 1, p. 120-128, JAN 2014. |
| Web of Science Citations: | 9 |
| Abstract | |
Introduction: Neuromuscular electrical stimulation (NMES) is used to improve quadriceps mass after anterior cruciate ligament (ACL) injury. We studied the effect of NMES on mRNA levels of atrophy genes in the quadriceps muscle of rats after ACL transection. Methods: mRNA levels of atrogin-1, MuRF-1, and myostatin were assessed by quantitative PCR and the polyubiquitinated proteins by Western blot at 1, 2, 3, 7, and 15 days postinjury. Results: NMES minimized the accumulation of atrogenes and myostatin according to time period. NMES also prevented reduction in muscle mass in all muscles of the ACLES group at 3 days. Conclusions: Use of NMES decreased the accumulation of atrogenes and myostatin mRNA in the quadriceps muscles, inhibiting early atrophy at 3 days, although it did not prevent atrophy at 7 and 15 days after ACL transection. This study highlights the importance of therapeutic NMES interventions in the acute phase after ACL transection. Muscle Nerve49: 120-128, 2014 (AU) | |
| FAPESP's process: | 08/09408-4 - The effect of electric stimulation in quadriceps femoris muscle atrophy after anterior cruciate ligament injury in rats |
| Grantee: | João Luiz Quagliotti Durigan |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 10/06940-7 - Effect of anterior cruciate ligament rupture on the expression of genes and proteins related to atrophy in quadriceps muscle of rats |
| Grantee: | Tania de Fatima Salvini |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 08/03499-8 - The effect of anterior cruciate ligament rupture in morphology, gene and protein expressions related to atrophy in the quadriceps femoral muscle of rats |
| Grantee: | Gabriel Borges Delfino |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 08/05237-0 - Possible efects of joint inflammation on skeletal muscle gene expression and morphology |
| Grantee: | Thiago Luiz de Russo |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |