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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reduction in prevalence of Archaea after periodontal therapy in subjects with generalized aggressive periodontitis

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Lira, E. A. G. [1] ; Ramiro, F. S. [1] ; Chiarelli, F. M. [1] ; Dias, R. R. [1] ; Feres, M. [1] ; Figueiredo, L. C. [1] ; Faveri, M. [1]
Total Authors: 7
[1] Univ Guarulhos, Dept Periodontol, Dent Res Div, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: AUSTRALIAN DENTAL JOURNAL; v. 58, n. 4, p. 442-447, DEC 2013.
Web of Science Citations: 7

Background: There is evidence of a possible relationship between Archaea and periodontal disease; however, to date few studies have assessed the changes in prevalence of this domain after periodontal therapy. The aim of this randomized double-blind and placebo-controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the prevalence of Archaea after periodontal therapy. Methods: Thirty subjects were randomly assigned to receive scaling and root planing (SRP) alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days. Clinical and microbiological examinations were performed at baseline and at six months post-SRP. Nine subgingival plaque samples per subject were analysed for the presence of Archaea. Results: SRP alone or combined with MTZ + AMX significantly reduced the prevalence of subjects colonized by Archaea at six months post-therapy. However, no significant differences between treatment groups were observed (p > 0.05). Both therapies led to a statistically significant decrease in the mean percentage of sites colonized by Archaea (p < 0.05). A negative Spearman correlation was observed between the presence of Archaea and the mean clinical attachment gain at six months post-therapy (r(2) = -0.61; 95% CI -0.80- -0.31; p = 0.003). Conclusions: SRP alone or combined with MTZ + AMX provides a similar reduction in the prevalence of Archaea in the subgingival biofilm of subjects with generalized aggressive periodontitis. (AU)

FAPESP's process: 09/11327-5 - Prevalence of microorganisms of archaea in subjects with generalized aggressive periodontitis after periodontal therapy
Grantee:Eisla Alline Gomes de Lira
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 07/56413-0 - Clinical and microbiological effects of amoxicillin and metronidazole systemic association to scaling and root planing in subjects with generalized aggressive periodontitis
Grantee:Marcelo de Faveri
Support type: Regular Research Grants