| Full text | |
| Author(s): |
Lira, E. A. G.
[1]
;
Ramiro, F. S.
[1]
;
Chiarelli, F. M.
[1]
;
Dias, R. R.
[1]
;
Feres, M.
[1]
;
Figueiredo, L. C.
[1]
;
Faveri, M.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Guarulhos, Dept Periodontol, Dent Res Div, Sao Paulo - Brazil
Total Affiliations: 1
|
| Document type: | Journal article |
| Source: | AUSTRALIAN DENTAL JOURNAL; v. 58, n. 4, p. 442-447, DEC 2013. |
| Web of Science Citations: | 7 |
| Abstract | |
Background: There is evidence of a possible relationship between Archaea and periodontal disease; however, to date few studies have assessed the changes in prevalence of this domain after periodontal therapy. The aim of this randomized double-blind and placebo-controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the prevalence of Archaea after periodontal therapy. Methods: Thirty subjects were randomly assigned to receive scaling and root planing (SRP) alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days. Clinical and microbiological examinations were performed at baseline and at six months post-SRP. Nine subgingival plaque samples per subject were analysed for the presence of Archaea. Results: SRP alone or combined with MTZ + AMX significantly reduced the prevalence of subjects colonized by Archaea at six months post-therapy. However, no significant differences between treatment groups were observed (p > 0.05). Both therapies led to a statistically significant decrease in the mean percentage of sites colonized by Archaea (p < 0.05). A negative Spearman correlation was observed between the presence of Archaea and the mean clinical attachment gain at six months post-therapy (r(2) = -0.61; 95% CI -0.80- -0.31; p = 0.003). Conclusions: SRP alone or combined with MTZ + AMX provides a similar reduction in the prevalence of Archaea in the subgingival biofilm of subjects with generalized aggressive periodontitis. (AU) | |
| FAPESP's process: | 07/56413-0 - Efeitos clinicos e microbiologicos da associacao sistemica de amoxilina e metronidazol a raspagem e elisamento radicular em individuos com doenca periodontal agressiva generalizada. |
| Grantee: | Marcelo de Faveri |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 09/11327-5 - Prevalence of microorganisms of Archaea in subjects with generalized aggressive periodontitis after periodontal therapy. |
| Grantee: | Eisla Alline Gomes de Lira |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |