Reduction in prevalence of Archaea after periodontal therapy in subjects with generalized aggressive periodontitis

Author(s)

Lira, E. A. G. ^[1] ; Ramiro, F. S. ^[1] ; Chiarelli, F. M. ^[1] ; Dias, R. R. ^[1] ; Feres, M. ^[1] ; Figueiredo, L. C. ^[1] ; Faveri, M. ^[1]

Affiliation

^[1] Univ Guarulhos, Dept Periodontol, Dent Res Div, Sao Paulo - Brazil

• Document type: Journal article
• Source: AUSTRALIAN DENTAL JOURNAL; v. 58, n. 4, p. 442-447, DEC 2013.
• Web of Science Citations: 7

Abstract

Background: There is evidence of a possible relationship between Archaea and periodontal disease; however, to date few studies have assessed the changes in prevalence of this domain after periodontal therapy. The aim of this randomized double-blind and placebo-controlled study was to assess if periodontal treatment with or without systemic antibiotic would change the prevalence of Archaea after periodontal therapy. Methods: Thirty subjects were randomly assigned to receive scaling and root planing (SRP) alone or combined with metronidazole (MTZ) + amoxicillin (AMX) for 14 days. Clinical and microbiological examinations were performed at baseline and at six months post-SRP. Nine subgingival plaque samples per subject were analysed for the presence of Archaea. Results: SRP alone or combined with MTZ + AMX significantly reduced the prevalence of subjects colonized by Archaea at six months post-therapy. However, no significant differences between treatment groups were observed (p > 0.05). Both therapies led to a statistically significant decrease in the mean percentage of sites colonized by Archaea (p < 0.05). A negative Spearman correlation was observed between the presence of Archaea and the mean clinical attachment gain at six months post-therapy (r(2) = -0.61; 95% CI -0.80- -0.31; p = 0.003). Conclusions: SRP alone or combined with MTZ + AMX provides a similar reduction in the prevalence of Archaea in the subgingival biofilm of subjects with generalized aggressive periodontitis. (AU)

• FAPESP's process: 07/56413-0 - Clinical and microbiological effects of amoxicillin and metronidazole systemic association to scaling and root planing in subjects with generalized aggressive periodontitis
• Grantee: Marcelo de Faveri
• Support Opportunities: Regular Research Grants
• FAPESP's process: 09/11327-5 - Prevalence of microorganisms of archaea in subjects with generalized aggressive periodontitis after periodontal therapy
• Grantee: Eisla Alline Gomes de Lira
• Support Opportunities: Scholarships in Brazil - Scientific Initiation