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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphisms in Genes Involved in Folate Metabolism Modify the Association of Dietary and Circulating Folate and Vitamin B-6 with Cervical Neoplasia

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Author(s):
Tomita, Luciana Y. [1] ; D'Almeida, Vania [2] ; Villa, Luisa L. [3, 4] ; Franco, Eduardo L. [5] ; Cardoso, Marly A. [6] ; Grp, BRINCA Study
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Prevent Med, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Radiol & Oncol, Sao Paulo - Brazil
[4] Canc Inst Sao Paulo State, Sao Paulo - Brazil
[5] McGill Univ, Div Canc Epidemiol, Montreal, PQ - Canada
[6] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Sao Paulo - Brazil
Total Affiliations: 6
Document type: Journal article
Source: Journal of Nutrition; v. 143, n. 12, p. 2007-2014, DEC 2013.
Web of Science Citations: 10
Abstract

High folate intake has been suggested as an important factor in cancer prevention; however, previous studies on the relation among folate intake, serum folate, and plasma homocysteine (hcy) are controversial. We conducted a hospital-based, case-control study in Brazil investigating associations between dietary and circulating vitamins B-6 and B-12 and folate, hcy, genotypes of folate-metabolizing enzyme methylenetetrahydrofolate reductase (MTHFR C677T, A1298C), 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR A2756G), methionine synthase reductase (MTRR A66G), and reduced folate carrier (RFC1 G80A) and risk of cervical intraepithelial neoplasia (CIN) grades 1 (CIN1), 2 (CIN2), and 3 (CIN3). The study was composed by 453 controls, 140 CIN1, 126 CIN2, and 231 CIN3. We investigated the joint effects of genetic variants of folate-related genes using genetic risk scores (GRSs) by summing the number of risk alleles for CIN1 and CIN2+ (CIN2 and CIN3 cases). The OR (95% CI) for CIN1 and CIN2+ per each risk allele were 1.29 (1.01, 1.65) and 1.22 (1.01, 1.46), respectively. An association between folate intake and CIN2+ was observed only after stratification according to GRS: crude OR (95% CI) for lower folate intake and GRS >= 4 was 1.67 (0.92, 3.04) (P-trend < 0.001) compared with higher folate intake (above the median) and GRS <= 3. The CIN2+ risk of lower serum vitamin B-6 and GRS >= 4 was 2.14 (0.92, 5.02) (P-trend = 0.05) and lower serum folate (below the median) and GRS >= 4 was 0.49 (0.20, 1.17) (P-trend = 0.05) after adjustment for confounding variables and human papillomavirus infection. Our data suggest that polymorphisrns in genes related to folate metabolism modify the association of dietary and circulating folate and vitamin B-6 with cervical neoplasia. (AU)

FAPESP's process: 02/11184-0 - Diet and serum micronutrients: association with cervical neoplasia and cancer
Grantee:Luciana Yuki Tomita
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 03/03013-4 - Diet and serum micronutrients: association with cervical neoplasia and cancer
Grantee:Marly Augusto Cardoso
Support Opportunities: Regular Research Grants