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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of chronic stress and high-fat diet on metabolic and nutritional parameters in Wistar rats

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Author(s):
Bruder-Nascimento, Thiago [1, 2] ; Salome Campos, Dijon Henrique [3] ; Alves, Carlos [3] ; Thomaz, Samuel [4] ; Cicogna, Antonio Carlos [3] ; Cordellini, Sandra [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Paulista, UNESP, Dept Pharmacol, Inst Biosci, Botucatu, SP - Brazil
[2] Univ Sao Paulo FMRP USP, Fac Med Ribeirao Preto, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[3] UNESP, Fac Med Botucatu, Dept Clin Med, Botucatu, SP - Brazil
[4] UNESP, Inst Biosci, Dept Morphol, Botucatu, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Arquivos Brasileiros de Endocrinologia e Metabologia; v. 57, n. 8, p. 642-649, NOV 2013.
Web of Science Citations: 25
Abstract

OBJECTIVE: The aim of this study was assess the role of chronic stress on the metabolic and nutritional profile of rats exposed to a high-fat diet. MATERIALS AND METHODS: Thirty-day-old male Wistar rats (70-100 g) were distributed into four groups: normal-diet (NC), chronic stress (St), high-fat diet (HD), and chronic stress/high-fat diet (HD/St). Stress consisted at immobilization during 15 weeks, 5 times per week, 1h per day; and exposure to the high-fat diet lasted 15 weeks. Nutritional and metabolic parameters were assessed. The level of significance was 5%. RESULTS: The HD group had final body weight, total fat, as well as insulin and leptin increased, and they were insulin resistant. The St and HD/St had arterial hypertension and increased levels of corticosterone. Stress blocked the effects of the high-fat diet. CONCLUSION: Chronic stress prevented the appearance of obesity. Our results help to clarify the mechanisms involved in metabolic and nutritional dysfunction, and contribute to clinical cases linked to stress and high-fat diet. (AU)

FAPESP's process: 09/03771-2 - Cardiovascular alterations in rats exposed or not to chronic stress during the obesity induction
Grantee:Thiago Bruder Do Nascimento
Support Opportunities: Scholarships in Brazil - Master