Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Differential pulse adsorptive stripping voltammetric determination of methotrexate using a functionalized carbon nanotubes-modified glassy carbon electrode

Full text
Oliveira, Geiser G. [1] ; Janegitz, Bruno C. [2] ; Zucolotto, Valtencir [2] ; Fatibello-Filho, Orlando [1]
Total Authors: 4
[1] Univ Fed Sao Carlos, Dept Chem, Ctr Sci & Technol, BR-13560970 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Nanomed & Nanotoxicol Grp, Sao Carlos Inst Phys, BR-13566590 Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CENTRAL EUROPEAN JOURNAL OF CHEMISTRY; v. 11, n. 11, p. 1837-1843, NOV 2013.
Web of Science Citations: 15

A glassy carbon electrode (GC) containing multiwalled functionalized carbon nanotubes (MWCNTs) immobilized within a dihexadecylhydrogenphosphate film (DHP) is proposed as a nanostructured platform for determination of methotrexate (MTX) concentration (a drug used in cancer treatment) using differential pulse adsorptive stripping voltammetry (DPAdSV). The voltammograms for a MTX solution using MWCNTs-DHP/GC electrode presented an oxidation peak potential at 0.98 V vs. Ag/AgCl (3.0 mol L-1 KCl) in a 0.1 mol L-1 sulphuric acid. The apparent heterogeneous electron transfer rate constant of 0.46 s(-1) was calculated. The recovery area of 2.62 x 10(-9) mol cm(2) was also obtained. Under the optimal experimental conditions, the analytical curve was linear in the MTX concentration range from 5.0 x 10(-8) to 5.0 x 10(-6) mol L-1, with a detection limit of 3.3 x 10(-8) mol L-1. The MWCNTs-DHP/GC electrode can be easily prepared and was applied for the determination of MTX in pharmaceutical formulations, with results similar to those obtained using a high-performance liquid chromatography comparative method. (AU)

FAPESP's process: 12/02877-4 - Development of new biosensors using active Nanoesctrutured materials
Grantee:Bruno Campos Janegitz
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 08/09893-0 - Development of biosensors using carbon nanotube and nanoparticles
Grantee:Bruno Campos Janegitz
Support type: Scholarships in Brazil - Doctorate