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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

COMMISSURAL NUCLEUS OF THE SOLITARY TRACT REGULATES THE ANTIHYPERTENSIVE EFFECTS ELICITED BY MOXONIDINE

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Author(s):
Totola, L. T. [1] ; Alves, T. B. [1] ; Takakura, A. C. [2] ; Ferreira-Neto, H. C. [1] ; Antunes, V. R. [1] ; Menani, J. V. [3] ; Colombari, E. [3] ; Moreira, T. S. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo - Brazil
[3] Sao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Neuroscience; v. 250, p. 80-91, OCT 10 2013.
Web of Science Citations: 12
Abstract

The rostral ventrolateral medulla (RVLM) contains the presympathetic neurons involved in cardiovascular regulation that has been implicated as one of the most important central sites for the antihypertensive action of moxonidine (an alpha 2-adrenergic and imidazoline agonist). Here, we sought to evaluate the cardiovascular effects produced by moxonidine injected into another important brain-stem site, the commissural nucleus of the solitary tract (commNTS). Mean arterial pressure (MAP), heart rate (HR), splanchnic sympathetic nerve activity (sSNA) and activity of putative sympathoexcitatory vasomotor neurons of the RVLM were recorded in conscious or urethane-anesthetized, and artificial ventilated male Wistar rats. In conscious or anesthetized rats, moxonidine (2.5 and 5 nmol/50 nl) injected into the commNTS reduced MAP, HR and sSNA. The injection of moxonidine into the commNTS also elicited a reduction of 28% in the activity of sympathoexcitatory vasomotor neurons of the RVLM. To further assess the notion that moxonidine could act in another brainstem area to elicit the antihypertensive effects, a group with electrolytic lesions of the commNTS or sham and with stainless steel guide-cannulas implanted into the 4th V were used. In the sham group, moxonidine (20 nmol/1 mu l) injected into 4th V decreased MAP and HR. The hypotension but not the bradycardia produced by moxonidine into the 4th V was reduced in acute (1 day) commNTS-lesioned rats. These data suggest that moxonidine can certainly act in other brainstem regions, such as commNTS to produce its beneficial therapeutic effects, such as hypotension and reduction in sympathetic nerve activity. (c) 2013 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 10/19336-0 - Pontine mechanisms involved in cardiorespiratory control during central or peripheral chemoreceptors activation
Grantee:Thiago dos Santos Moreira
Support Opportunities: Regular Research Grants
FAPESP's process: 10/09776-3 - Neural mechanisms involved in expiratory rhythm generator: possible involvement of the retrotrapezoid nucleus and the parafacial region
Grantee:Ana Carolina Takakura Moreira
Support Opportunities: Research Grants - Young Investigators Grants
FAPESP's process: 09/54888-7 - Neural mechanisms involved on chemoreception
Grantee:Eduardo Colombari
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 11/50770-1 - Neural mechanisms involved of hydroelectrolytic balance and cardiorespiratory control
Grantee:José Vanderlei Menani
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 11/11934-9 - Evaluation of cardiovascular and sympathetic responses promoted by moxonidine injection in the commissural nucleus of the solitary tract in rats.
Grantee:Thales Biffe Alves
Support Opportunities: Scholarships in Brazil - Doctorate