Polymeric Systems as Nanodevices for siRNA Delivery

Author(s)

Tiera, Marcio J. ^[1] ; Shi, Qin ^[2] ; Goncalves Barbosa, Hellen Franciane ^[1] ; Fernandes, Julio C. ^[2]

Affiliation

^[1] UNESP Sao Paulo State Univ, Dept Chem & Environm Sci, Sao Jose Do Rio Preto - Brazil

^[2] Univ Montreal, Hop Sacre Coeur Montreal, Orthoped Res Lab, Montreal, PQ - Canada

• Document type: Journal article
• Source: CURRENT GENE THERAPY; v. 13, n. 5, p. 358-369, OCT 2013.
• Web of Science Citations: 7

Abstract

The delivery of small interfering RNAs (siRNAs) is a promising approach to silencing gene expression aimed at treating infections, cancer, neurodegenerative diseases and various other disorders. Recent progress in this area has been achieved with nanodevices possessing multiple properties and assembled with new, biodegradable, synthetic polymers and polysaccharides. Different synthetic routes and multiple strategies, such as multilayer systems and stimuli-responsive polymers, have been developed to attain high efficiencies. This review covers the most important, promising and successful approaches to improve siRNA delivery. It is a concise report on multiple strategies employed, including cell-specific delivery coupling ligands or antibodies with nanodevices to improve siRNA efficiency and specificity. (AU)

• FAPESP's process: 11/18692-0 - Non-viral gene therapy: synthesis, characterization and transfection studies of site-targeted nanocarriers based on biocompatible polycations
• Grantee: Marcio José Tiera
• Support Opportunities: Regular Research Grants