An Eco-Friendly Asymmetric Organocatalytic Conjugate Addition of Malonates to ,-Unsaturated Aldehydes: Application on the Synthesis of Chiral Indoles

Feu, Karla Santos; Deobald, Anna Maria; Narayanaperumal, Senthil; Correa, Arlene G.; Paixao, Marcio Weber

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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An Eco-Friendly Asymmetric Organocatalytic Conjugate Addition of Malonates to ,-Unsaturated Aldehydes: Application on the Synthesis of Chiral Indoles

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Author(s):	Feu, Karla Santos ^[1] ; Deobald, Anna Maria ^[1] ; Narayanaperumal, Senthil ^[1] ; Correa, Arlene G. ^[1] ; Paixao, Marcio Weber ^[1] Total Authors: 5
Affiliation:	^[1] Fed Univ Sao Carlos UFSCar, Dept Chem, BR-13565905 Sao Carlos, SP - Brazil Total Affiliations: 1
Document type:	Journal article
Source:	EUROPEAN JOURNAL OF ORGANIC CHEMISTRY; v. 2013, n. 26, p. 5917-5922, SEP 2013.
Web of Science Citations:	12
Abstract
The asymmetric Michael addition of malonates to ,-unsaturated aldehydes using a modified JOrgensen-Hayashi organocatalyst in EtOH:brine solvent media is reported. The procedure proceeds smoothly to afford the corresponding Michael adducts in good yields with excellent enantioselectivities. The resulting Michael adducts represent excellent building blocks for the synthesis of chiral indoles. (AU)

FAPESP's process:	09/07281-0 - Asymmetric organocatalysis: design of new organocatalysts and development of new methodologies
Grantee:	Márcio Weber Paixão
Support Opportunities:	Research Grants - Young Investigators Grants

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