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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Genomic mosaicism in two strains of dengue virus type 3

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Author(s):
Villabona-Arenas, Christian Julian [1] ; de Brito, Anderson Fernandes [1] ; de Andrade Zanotto, Paolo Marinho [1]
Total Authors: 3
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Mol Evolut & Bioinformat, BR-05508000 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: INFECTION GENETICS AND EVOLUTION; v. 18, p. 202-212, AUG 2013.
Web of Science Citations: 5
Abstract

Recombination is a significant factor driving genomic evolution, but it is not well understood in Dengue virus. We used phylogenetic methods to search for recombination in 636 Dengue virus type 3 (DENV-3) genomes and unveiled complex recombination patterns in two strains, which appear to be the outcome of recombination between genotype II and genotype I parental DENV-3 lineages. Our findings of genomic mosaic structures suggest that strand switching during RNA synthesis may be involved in the generation of genetic diversity in dengue viruses. (C) 2013 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/17071-2 - Phylogeography of urban outbreaks of dengue virus in Jundiaí and Guarujá in the State of São Paulo
Grantee:Christian Julián Villabona Arenas
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 10/19059-7 - Phylogeography of urban outbreaks of dengue virus in Jundiaí and Guarujá in the State of São Paulo
Grantee:Paolo Marinho de Andrade Zanotto
Support Opportunities: Regular Research Grants
FAPESP's process: 11/14537-0 - Genomic diversity analysis of geographic isolates of nucleopolyhedroviruses Anticarsia gemmatalis (AgMNPV)
Grantee:Anderson Fernandes de Brito
Support Opportunities: Scholarships in Brazil - Master