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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Metronidazole alone or with amoxicillin as adjuncts to non-surgical treatment of chronic periodontitis: a secondary analysis of microbiological results from a randomized clinical trial

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Author(s):
Soares, Geisla M. S. [1] ; Mendes, Juliana A. V. [1] ; Silva, Maike P. [1] ; Faveri, Marcelo [1] ; Teles, Ricardo [2, 3] ; Socransky, Sigmund S. [3] ; Wang, Xiaoshan [3] ; Figueiredo, Luciene C. [1] ; Feres, Magda [1]
Total Authors: 9
Affiliation:
[1] Univ Guarulhos, Dept Periodontol, Dent Res Div, Sao Paulo - Brazil
[2] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 - USA
[3] Forsyth Inst, Dept Appl Oral Sci, Cambridge, MA - USA
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF CLINICAL PERIODONTOLOGY; v. 41, n. 4, p. 366-376, APR 2014.
Web of Science Citations: 27
Abstract

Aim To evaluate the changes occurring in the subgingival microbial profile of subjects with generalized chronic periodontitis (ChP) treated by scaling and root planing (SRP) alone or with metronidazole (MTZ) or MTZ+amoxicillin (AMX). A secondary aim was to examine a possible added effect of chlorhexidine (CHX) to these therapies. Methods One hundred and eighteen subjects were randomly assigned to receive SRP-only or with MTZ {[}400mg/thrice a day (TID)] or MTZ+AMX (500mg/TID) for 14days. Half of the subjects in each group rinsed with 0.12% CHX twice a day (BID) for 2months. Nine subgingival plaque samples/subject were analysed by checkerboard DNA-DNA hybridization for 40 bacterial species at baseline, 3, 6 and 12months post-therapy. Results At 12months, the antibiotic-treated groups harboured lower mean counts and proportions of key periodontal pathogens than the SRP group (p<0.05). These benefits were observed at initially deep and shallow sites. Initial reductions in periodontal pathogens obtained with SRP partially rebound after 12months. CHX rinsing enhanced the microbiological effects of the MTZ+AMX treatment in shallow sites. Conclusion The adjunctive use of MTZ and MTZ+AMX results in a greater reduction in the levels of periodontal pathogens in generalized ChP subjects compared to SRP alone. (AU)