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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A new platinum complex with tryptophan: Synthesis, structural characterization, DFT studies and biological assays in vitro over human tumorigenic cells

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Author(s):
Carvalho, Marcos A. [1] ; Shishido, Silvia M. [2] ; Souza, Barbara C. [1] ; de Paiva, Raphael E. F. [1] ; Gomes, Alexandre F. [3] ; Gozzo, Fabio C. [3] ; Formiga, Andre L. B. [4] ; Corbi, Pedro P. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Bioinorgan & Med Chem Res Lab, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Lab Bioassays & Signal Transduct, Dept Biochem, BR-13083970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, UNICAMP, Inst Chem, Dalton Mass Spectrometry Lab, Organ Chem Dept, BR-13083970 Campinas, SP - Brazil
[4] Univ Estadual Campinas, UNICAMP, Inst Chem, Coordinat Chem Lab, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY; v. 122, p. 209-215, MAR 25 2014.
Web of Science Citations: 9
Abstract

A new platinum(II) complex with the amino acid L-tryptophan (trp), named Pt-trp, was synthesized and characterized. Elemental, thermogravimetric and ESI-QTOF mass spectrometric analyses led to the composition {[}Pt(C11H11N2O2)(2)]center dot 6H(2)O. Infrared spectroscopic data indicate the coordination of trp to Pt(II) through the oxygen of the carboxylate group and also through the nitrogen atom of the amino group. The C-13 CP/MAS NMR spectroscopic data confirm coordination through the oxygen atom of the carboxylate group, while the N-15 CP/MAS NMR data confirm coordination of the nitrogen of the NH2 group to the metal. Density functional theory (DFT) studies were applied to evaluate the as and trans coordination modes of trp to platinum(II). The trans isomer was shown to be energetically more stable than the cis one. The Pt-trp complex was evaluated as a cytotoxic agent against SK-Mel 103 (human melanoma) and Panc-1 (human pancreatic carcinoma) cell lines. The complex was shown to be cytotoxic over the considered cells. (C) 2013 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/08230-2 - Synthesis, characterization and pharmacological studies of Ag(I), Au(I), Pt(II) and Pd(II) complexes with bioactive ligands
Grantee:Pedro Paulo Corbi
Support Opportunities: Regular Research Grants