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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thermoanalytical study of nimesulide and their recrystallization products obtained from solutions of several alcohols

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Author(s):
Galico, D. A. [1] ; Perpetuo, G. L. [1] ; Castro, R. A. E. [2] ; Treu-Filho, O. [3] ; Legendre, A. O. [1] ; Galhiane, M. S. [1] ; Bannach, G. [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista, UNESP, Fac Ciencias, Dept Quim, BR-17033260 Sao Paulo - Brazil
[2] Univ Coimbra, Fac Farm, CEF, P-3000548 Coimbra - Portugal
[3] Univ Estadual Paulista, UNESP, Inst Quim, BR-14800900 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY; v. 115, n. 3, p. 2385-2390, MAR 2014.
Web of Science Citations: 11
Abstract

Thermogravimetry, differential scanning calorimetry, and vibrational infrared spectroscopy were used to study nimesulide and its recrystallization products that were obtained from solutions of several alcohols. The thermoanalytical measurements were performed in both air and nitrogen atmospheres and the results suggest that, under the experimental conditions used in this paper, it was possible to obtain neither polymorphic nor pseudopolymorphic forms of this drug. In this investigation, quantum chemical approach methods were used to determine the molecular structures using the Becke three-parameter hybrid method and the Lee-Yang-Parr correlation functional. The performed molecular calculations were done with the Gaussian 09 routine and the theoretical calculation results were correlated with the experimental IR vibrational spectrum. (AU)

FAPESP's process: 12/21450-1 - Thermoanalytical studies, synthesis and characterization of the solid co-crystals of ketoprofen with some co-formers
Grantee:Gilbert Bannach
Support Opportunities: Regular Research Grants