Chemotherapy-Induced Oral Mucositis: Effect of LED and Laser Phototherapy Treatment Protocols

Author(s)

Carneiro Freitas, Ana Carolina ^[1] ; Campos, Luana ^[1] ; Brandao, Thais Bianca ^[2] ; Cristofaro, Marcio ^[3] ; Eduardo, Fernanda de Paula ^[4] ; Luiz, Ana Claudia ^[2] ; Marques, Marcia Martins ^[5] ; Eduardo, Carlos de Paula ^[6] ; Simoes, Alyne ^[1]

Affiliation

^[1] Univ Sao Paulo, Fac Odontol, Dept Biomat & Biol Oral, BR-05508900 Sao Paulo - Brazil

^[2] Inst Canc Estado Sao Paulo, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Odontol, Dept Estomatol, BR-05508900 Sao Paulo - Brazil

^[4] Hosp Israelita Albert Einstein, Sao Paulo - Brazil

^[5] Dept Dent Restauradora FOUSP, Sao Paulo - Brazil

^[6] FOUSP, Dept Dent Restauradora, LELO, Sao Paulo - Brazil

• Document type: Journal article
• Source: Photomedicine and Laser Surgery; v. 32, n. 2, p. 81-87, FEB 1 2014.
• Web of Science Citations: 10

Abstract

Background and objective: Over the last few decades, many studies have focused on the effect of lasers on the management of oral mucositis in oncologic patients treated with chemotherapy and/or radiotherapy. However, the effect of light-emitting diode (LED) has been poorly studied, and was not compared with that of laser phototherapy (LPT). For this reason, the aim of the present study was to clinically compare the effect of these two therapies on chemotherapy-induced oral mucositis (CIOM) and pain. Methods: Forty patients with CIOM were divided into two groups: G1, patients treated with LPT; G2, patients treated with LED. The treatment was administered during 10 consecutive days, with exception of weekends. LPT was applied using an InGaAlP laser (660nm/40mW/6.6J cm-(2)/0.24J per point/0.036cm(2) of spot size). LED phototherapy was applied using 0.24J per point/80mW/630nm/1cm(2) of spot size. CIOM was assessed during each session in accordance to the World Health Organization (WHO) score. The patient self-assessed pain was scored on a visual analog scale (VAS). Results: The mean VAS and WHO scores were significantly smaller in the LED group (p<0.05). However, both groups required the same number of days to reach score zero for mucositis and pain (p>0.05). Moreover, in the group with severe mucositis (score III), there was a lower frequency of patients with complete healing and pain relief, with the exception of analgesia in G2, in which almost all patients were completely relieved from pain. Conclusions: These findings suggest that LED therapy is more effective than LPT in the treatment of COIM, with the parameters used in the present study. (AU)

• FAPESP's process: 11/14013-1 - Comparative study of different phototherapies (LED, high and low power lasers) on oral mucositis and laser effect upon salivary glands hypofunction both induced by 5-fluorouracil in hamsters
• Grantee: Alyne Simões Gonçalves
• Support Opportunities: Regular Research Grants
• FAPESP's process: 10/03662-6 - Comparative study between LED and laser as phototherapies against chemotherapy-induced oral mucositis
• Grantee: Alyne Simões Gonçalves
• Support Opportunities: Regular Research Grants