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Comparative study of different phototherapies (LED, high and low power lasers) on oral mucositis and laser effect upon salivary glands hypofunction both induced by 5-fluorouracil in hamsters

Grant number: 11/14013-1
Support type:Regular Research Grants
Duration: November 01, 2011 - October 31, 2013
Field of knowledge:Health Sciences - Dentistry
Principal researcher:Alyne Simões Gonçalves
Grantee:Alyne Simões Gonçalves
Home Institution: Faculdade de Odontologia (FO). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Assoc. researchers:Victor Elias Arana-Chavez


Oral mucositis and hyposalivation/xerostomia are dose-limited debilitating consequences from antineoplastic treatment. Several literature articles have shown the positive effects from different phototherapy modalities on the treatment of these complications, however, the action mechanism of these phototherapies upon oral mucosa and salivary glands is yet not totally known. Thus, the aim of this study is to compare, through biochemical and histological analysis, different photherapies on the treatment of oral mucositis and salivary glands hypofunction induced by two injections of 5-Fluorouracil (100 mg/kg and 65 mg/kg, respectively) in Syrian (golden) hamsters. The animals will be divided into two major groups, control and experimental, which will be subdivided in group C: anesthesia and CQ: anesthesia and chemotherapy/oral mucositis, for control group and in group L: anesthesia, chemotherapy/oral mucositis and phototherapy (LED, 1,2 J/cm², 1.2 J of total energy), LA: anesthesia, chemotherapy/oral mucositis and phototherapy (high-power laser, 10 J/cm², 10 J of total energy), LB: anesthesia, chemotherapy/oral mucositis and phototherapy (low-power laser, 6 J/cm², 1.2 J of total energy) and LG: anesthesia, chemotherapy and phototherapy on salivary gland areas (low-power laser, 5 J/cm2 on salivary glands) for experimental group. The oral mucositis will be induced by slots on oral mucosa which will be performed after chemoterapy treatment. The oral mucositis will be analyzed through a clinical scale and after 5, 10 and 15 days, the animals will be sacrificed and the oral mucosa and parotid and submandibular glands will be removed for histological and biochemical analysis. (AU)

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Scientific publications (8)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAMPOS, LUANA; COTOMACIO, CLAUDIA CARRARA; ARANA-CHAVEZ, VICTOR ELIAS; SIMOES, ALYNE. Phototherapy With LED as an Effective Treatment for Chemotherapy-Induced Oral Mucositis in Hamsters. JOURNAL OF LASERS IN MEDICAL SCIENCES, v. 11, n. 4, p. 475-480, FAL 2020. Web of Science Citations: 0.
DE CASTRO, JULIANA R.; DE SOUZA, EUGEN M. N.; PARK, YUN-JONG; DE CAMPOS, LUANA; CHA, SEUNGHEE; ARANA-CHAVEZ, VICTOR E.; NICOLAU, JOSE; SIMOES, ALYNE. Low-power laser irradiation decreases lipid droplet accumulation in the parotid glands of diabetic rats. Journal of Biophotonics, v. 11, n. 4 APR 2018. Web of Science Citations: 0.
COTOMACIO, CLAUDIA CARRARA; CAMPOS, LUANA; DE SOUZA, DOUGLAS NESADAL; ARANA-CHAVEZ, VICTOR ELIAS; SIMOES, ALYNE. Dosimetric study of photobiomodulation therapy in 5-FU-induced oral mucositis in hamsters. Journal of Biomedical Optics, v. 22, n. 1 JAN 2017. Web of Science Citations: 2.
CAMPOS, LUANA; CRUZ, ERIKA P.; PEREIRA, FILIPI S.; ARANA-CHAVEZ, VICTOR E.; SIMOES, ALYNE. Comparative study among three different phototherapy protocols to treat chemotherapy-induced oral mucositis in hamsters. Journal of Biophotonics, v. 9, n. 11-12, SI, p. 1236-1245, DEC 2016. Web of Science Citations: 10.
DA CRUZ, ERIKA DE PAULA; CAMPOS, LUANA; PEREIRA, FILIPI DA SILVA; MAGLIANO, GABRIELA CAMPOS; BENITES, BERNAR MONTEIRO; ARANA-CHAVEZ, VICTOR ELIAS; BALLESTER, RAFAEL YAGUE; SIMOES, ALYNE. Clinical, biochemical and histological study of the effect of antimicrobial photodynamic therapy on oral mucositis induced by 5-fluorouracil in hamsters. Photodiagnosis and Photodynamic Therapy, v. 12, n. 2, p. 298-309, JUN 2015. Web of Science Citations: 11.
CAMPOS, LUANA; NICOLAU, JOSE; ARANA-CHAVEZ, VICTOR E.; SIMOES, ALYNE. Effect of Laser Phototherapy on Enzymatic Activity of Salivary Glands of Hamsters Treated with 5-Fluorouracil. Photochemistry and Photobiology, v. 90, n. 3, p. 667-672, MAY 2014. Web of Science Citations: 1.
CARNEIRO FREITAS, ANA CAROLINA; CAMPOS, LUANA; BRANDAO, THAIS BIANCA; CRISTOFARO, MARCIO; EDUARDO, FERNANDA DE PAULA; LUIZ, ANA CLAUDIA; MARQUES, MARCIA MARTINS; EDUARDO, CARLOS DE PAULA; SIMOES, ALYNE. Chemotherapy-Induced Oral Mucositis: Effect of LED and Laser Phototherapy Treatment Protocols. Photomedicine and Laser Surgery, v. 32, n. 2, p. 81-87, FEB 1 2014. Web of Science Citations: 10.
IBUKI, FLAVIA KAZUE; SIMOES, ALYNE; NICOLAU, JOSE; NOGUEIRA, FERNANDO NEVES. Laser irradiation affects enzymatic antioxidant system of streptozotocin-induced diabetic rats. Lasers in Medical Science, v. 28, n. 3, p. 911-918, MAY 2013. Web of Science Citations: 11.

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