Analysis of the effects of the purified oleanolic and ursolic acids from Baccharis...
| Author(s): |
Greeco, Simone dos S.
[1, 2]
;
Felix, Maria Julia P.
[1]
;
Lago, Joao Henrique G.
[1]
;
Pinto, Erika G.
[3, 4]
;
Tempone, Andre G.
[5]
;
Romoff, Paulete
[5]
;
Ferreira, Marcelo Jose P.
[5]
;
Sartorelli, Patricia
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmacet, BR-09972270 Diadema, SP - Brazil
[2] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-0909040 Santo Andre, SP - Brazil
[3] Adolfo Lutz Inst, Dept Parasitol, BR-01246000 Sao Paulo - Brazil
[4] Univ Sao Paulo, Inst Med Trop Sao Paulo, BR-05304000 Sao Paulo - Brazil
[5] Univ Presbiteriana Mackenzie, Ctr Ciencias & Humanidades, BR-01302907 Sao Paulo - Brazil
Total Affiliations: 5
|
| Document type: | Journal article |
| Source: | NATURAL PRODUCT COMMUNICATIONS; v. 9, n. 2, p. 171-173, FEB 2014. |
| Web of Science Citations: | 11 |
| Abstract | |
Bioassay-guided fractionation of the EtOH extract of the aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to identification of two cinnamic acid derivatives (caffeic and ferulic acids), two flavones (hispidulin and pectolinaringenin) and a mixture of three chlorogenic acids (3,4-, 3,5- and 4,5-O-dicaffeoylquinic acids), which displayed in vitro anti-trypanosomal activity. Pectolinaringenin, hispidulin and caffeic acid showed activity against trypomastigotes of Trypanosoma cruzi, exhibiting 50% inhibitory concentration (IC50) values of 52, 81 and 56 mu g/mL, respectively, while the chlorogenic acid mixture showed an IC50 value of 61 mu g/mL. The flavonoids and cinnamic acid derivatives were evaluated for cytotoxicity against NCTC cells resulting in a 50% cytotoxic concentration (CC50) ranging from 33.82 to 129.1 mu g/mL while the chlorogenic acids did not display cytotoxicity (CC50 >150 mu g/mL). This is the first report of anti-trypanosomal activity of compounds from B. uncinella. (AU) | |
| FAPESP's process: | 11/51739-0 - Sustainable use of biodiversity in Atlantic Forest remnants in São Paulo: evaluation, isolation and molecular characterization of bioactive secondary metabolites in plant species |
| Grantee: | João Henrique Ghilardi Lago |
| Support type: | BIOTA-FAPESP Program - Regular Research Grants |