NF-kappa B and COX-2 Expression in Nonmalignant Endometrial Lesions and Cancer

Author(s)

Faloppa, Carlos Chaves ^[1] ; Baiocchi, Glauco ^[1] ; Cunha, Isabela Werneck ^[2] ; Tavares Guerreiro Fregnani, Jose Humberto ^[3] ; Bueno Toledo Osorio, Cynthia Aparecida ^[2] ; Fukazawa, Elza Mieko ^[1] ; Kumagai, Lillian Yuri ^[1] ; Badiglian-Filho, Levon ^[1] ; Souza Pinto, Gabriel Lowndes ^[4] ; Soares, Fernando Augusto ^[2]

Affiliation

^[1] AC Camargo Canc Hosp, Dept Gynecol Oncol, Sao Paulo - Brazil

^[2] AC Camargo Canc Hosp, Dept Pathol, Sao Paulo - Brazil

^[3] Barretos Canc Hosp, Dept Gynecol Oncol, Barretos - Brazil

^[4] Brazilian Inst Canc Control, Dept Gynecol Oncol, Sao Paulo - Brazil

• Document type: Journal article
• Source: AMERICAN JOURNAL OF CLINICAL PATHOLOGY; v. 141, n. 2, p. 196-203, FEB 2014.
• Web of Science Citations: 8

Abstract

Objectives: To examine the immunohistochemical expression of cyclooxygenase-2 (COX-2) and nuclear factor-kappa B (NF-kappa B) in benign endometrial polyps (EPs), endometrial hyperplasia (EH), endometrial intraepithelial neoplasia (EIN), and endometrioid endometrial cancer (EC). Methods: The immunohistochemical expression of COX-2 and NF-kappa B was performed using an Aperio Scanscope XT automated system in 218 patients with endometrioid EC and 107 patients with nonmalignant endometrial lesions: 53 with benign EPs, 37 with EH, and 17 with EIN. Results: COX-2 and NF-kappa B p50 expression were significantly lower in EC compared with nonmalignant lesions. We observed significant decreased NF-kappa B p65 expression in EC vs EPs (P < .001) and EH (P = .014) as well as in EIN vs EPs (P = .01). For patients with EC, COX-2 correlated positively with NF-kappa B p65 and NF-kappa B p50 (P < .001). Grade 3 tumors had a higher mean expression of NF-kappa B p65 (P = .03). NF-kappa B p50, NF-kappa B p65, and COX-2 expression had no impact on survival. Conclusions: We conclude that COX-2 and NF-kappa B expression are lower in EC compared with nonmalignant endometrial lesions. COX-2 and NF-kappa B expression have no prognostic value in EC. (AU)

• FAPESP's process: 09/52778-0 - Immunohistochemistry analysis of NF-kB and COX-2 expression in endometrial diseases
• Grantee: José Humberto Tavares Guerreiro Fregnani
• Support Opportunities: Regular Research Grants