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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acute Aerobic Exercise Increases Brain-Derived Neurotrophic Factor Levels in Elderly with Alzheimer's Disease

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de Melo Coelho, Flavia Gomes [1] ; Vital, Thays Martins [1] ; Stein, Angelica Miki [1] ; Arantes, Franciel Jose [1] ; Rueda, Andre Veloso [2] ; Camarini, Rosana [2] ; Teodorov, Elizabeth [3] ; Santos-Galduroz, Ruth Ferreira [3, 1]
Total Authors: 8
[1] Univ Estadual Paulista, UNESP, Inst Biosci, Phys Activ & Aging Lab LAFE, Rio Claro, SP - Brazil
[2] Univ Sao Paulo, Dept Pharmacol, Inst Biomed Sci, USP, Lab Neurochem & Behav Pharmacol, Sao Paulo - Brazil
[3] Univ Fed ABC, UFABC, Ctr Math Comp & Cognit, Santo Andre, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF ALZHEIMER'S DISEASE; v. 39, n. 2, p. 401-408, 2014.
Web of Science Citations: 72

Studies indicate the involvement of brain-derived neurotrophic factor (BDNF) in the pathogenesis of Alzheimer's disease (AD). Decreased BDNF levels may constitute a lack of trophic support and contribute to cognitive impairment in AD. The benefits of acute and chronic physical exercise on BDNF levels are well-documented in humans, however, exercise effects on BDNF levels have not been analyzed in older adults with AD. The aim of this study was to investigate the effects of acute aerobic exercise on BDNF levels in older adults with AD and to verify associations among BDNF levels, aerobic fitness, and level of physical activity. Using a controlled design, twenty-one patients with AD (76.3 +/- 6.2 years) and eighteen healthy older adults (74.6 +/- 4.7 years) completed an acute aerobic exercise. The outcomes included measures of BDNF plasma levels, aerobic fitness (treadmill grade, time to exhaustion, VO2, and maximal lactate) and level of physical activity (Baecke Questionnaire Modified for the Elderly). The independent t-test shows differences between groups with respect to the BDNF plasma levels at baseline (p = 0.04; t = 4.53; df = 37). In two-way ANOVA, a significant effect of time was found (p = 0.001; F = 13.63; df = 37), the aerobic exercise significantly increased BDNF plasma levels in AD patients and healthy controls. A significant correlation (p = 0.04; r = 0.33) was found between BDNF levels and the level of physical activity. The results of our study suggest that aerobic exercise increases BDNF plasma levels in patients with AD and healthy controls. In addition to that, BDNF levels had association with level of physical activity. (AU)

FAPESP's process: 11/10051-6 - Effect of aerobic training on plasma levels of brain-derived neurotrophic factor, metabolic variables and cognitive functions in elderly with Alzheimer's disease
Grantee:Flávia Gomes de Melo Coelho
Support Opportunities: Scholarships in Brazil - Doctorate